Antibody-Drug Conjugates : The 21st Century Magic Bullets for Cancer

Contents -- About the Editors -- Contributors -- Part I -- Introduction -- Chapter-1 -- Antibody-Drug Conjugates: A Historical Review -- References -- Part II -- The ADC Construct -- Chapter-2 -- Payloads of Antibody-Drug Conjugates -- 2.1 Introduction -- 2.2 Maytansinoids -- 2.2.1 Chemistry and Anticancer Activity -- 2.2.2 Mechanism of Action -- 2.2.3 Early Preclinical and Clinical Experiences -- 2.2.4 ADC Development -- 2.3 Auristatins -- 2.3.1 Chemistry and Anticancer Activity -- 2.3.2 Mechanism of Action -- 2.3.3 Early Preclinical and Clinical Experiences -- 2.3.4 ADC Development -- 2.4 Calicheamicins -- 2.4.1 Chemistry and Anticancer Activity -- 2.4.2 Mechanism of Action -- 2.4.3 Early Preclinical Experiences -- 2.4.4 ADC Development -- References -- Chapter-3 -- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy -- 3.1 Target Selection for an ADC -- 3.1.1 Characteristics of an Optimal ADC Target -- 3.1.2 Selection and Validation of Tumor-Associated Targets Using Omics Approaches -- 3.2 Antibody Characteristics -- 3.2.1 Optimal Antibody Characteristics -- 3.2.2 Engineering pH Dependence of Antibody Binding -- 3.2.3 Engineering Fc-Mediated Interactions -- 3.3 Agnostic Approach to Antibody Production -- 3.4 Target-First Approach to Antibody Generation -- 3.4.1 Considerations and Preparation of Target for Antibody Screening -- 3.4.2 Approaches to Antibody Isolation -- 3.5 Screening for Internalization and Intracellular Trafficking -- 3.5.1 Screening by Microscopy and Flow Cytometry -- 3.5.2 Screening for Intracellular Toxin Delivery -- 3.6 Payload Conjugation Strategies -- 3.7 Conclusions and Perspectives -- References -- Chapter-4 -- Linker Design for Antibody-Drug Conjugates -- 4.1 Introduction -- 4.2 Sites of Attachment and Reactive Chemical Moieties on Linkers -- 4.3 Types of Linkers -- 4.3.1 Noncleavable Linkers..

Medienart:	E-Book

Erscheinungsjahr:	2015 ©2015
Erschienen:	Cham: Springer International Publishing AG ; 2015 ©2015
Ausgabe:	1st ed.

Reihe:	AAPS Advances in the Pharmaceutical Sciences Ser. - v.17

Sprache:	Englisch

Beteiligte Personen:	Wang, Jeffrey [VerfasserIn] Shen, Wei-Chiang [Mitwirkende/r] Zaro, Jennica L. [Mitwirkende/r]

Links:	ebookcentral.proquest.com [lizenzpflichtig]

ISBN:	978-3-319-13081-1

Themen:	Antibody-drug conjugates.. Antibody-toxin conjugates Electronic books

Anmerkungen:	Description based on publisher supplied metadata and other sources

Umfang:	1 online resource (248 pages)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1746143991