Translational Biotechnology : A Journey from Laboratory to Clinics

Front Cover -- Translational Biotechnology -- Copyright Page -- Contents -- List of contributors -- Preface -- 1 Introduction to translational biotechnology -- 1 Translational biotechnology: A transition from basic biology to evidence-based research -- 1.1 Introduction -- 1.1.1 Background and emergence of the field -- 1.2 The phases of translational research -- 1.3 Challenges to solutions -- 1.4 Applications -- 1.4.1 Drug development -- 1.4.1.1 Protein drugs -- 1.4.1.2 Hormones -- 1.4.1.3 Monoclonal antibodies -- 1.4.1.4 Cytokines -- 1.4.1.5 Vaccines -- 1.4.2 Nanomedicine -- 1.4.3 Gene therapy -- 1.4.4 Precision medicine and biomarker development -- 1.4.5 Microbial engineering for bio-therapeutics -- 1.4.6 Application of big data and translational bioinformatics -- 1.5 Conclusion and future directions -- 1.6 Highlights -- Acknowledgment -- Conflict of interest -- References -- 2 Biotherapeutics -- 2 Biotechnology-based therapeutics -- 2.1 Introduction -- 2.2 Human gene therapy -- 2.2.1 Somatic cell gene therapy -- 2.2.2 Germline gene therapy -- 2.2.3 Gene transfer system -- 2.2.3.1 Nonbiological delivery system -- 2.2.3.1.1 Physical method -- Sonoporation -- Electroporation -- Magnetofection -- Hydroporation -- Gene gun -- 2.2.3.1.2 Chemical method -- Liposomes -- Polymers -- Heat shock -- 2.2.3.1.3 Biological method -- Bacterial vector -- Viral vector -- Retroviral vectors -- Adenoviral vectors -- Adeno-associated vectors -- Herpes simplex virus -- 2.2.4 Gene-editing technology -- 2.2.4.1 Zinc-finger nucleases -- 2.2.4.2 Transcription activator-like effector nucleases -- 2.2.4.3 Clustered regularly interspaced short palindromic repeat-Cas-associated nucleases -- 2.2.5 Ethical issue -- 2.3 Stem cell therapy -- 2.3.1 Sources of stem cells -- 2.3.1.1 Pluripotent stem cells -- 2.3.1.2 Multipotent stem cells..

Medienart:	E-Book

Erscheinungsjahr:	2021 ©2021
Erschienen:	San Diego: Elsevier Science & Technology ; 2021 ©2021

Sprache:	Englisch

Beteiligte Personen:	Hasija, Yasha [VerfasserIn]

Links:	ebookcentral.proquest.com [lizenzpflichtig] Inhaltsverzeichnis

ISBN:	978-0-12-821973-7

Themen:	Electronic books

Anmerkungen:	Description based on publisher supplied metadata and other sources

Umfang:	1 online resource (453 pages)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1745949240