Comparative efficacy and Long-Term Cost-Utility of combined cataract and minimally invasive Glaucoma surgery in German patients with Primary Open-Angle Glaucoma / submitted by José Bartel-Hofer ; 1. Gutachter: Prof. Dr. rer. pol. Steffen Fleßa, 2. Gutachter: Prof. Dr. Walter Ried

Glaukom, Nutzen, Stent, Cost-Effectiveness, Cost-Utility, Minimally Invasive Glaucoma Surgeries, Primary Open-Angle Glaucoma.

Purpose: To assess the comparative efficacy and the long-term cost-utility of alternative minimally invasive glaucoma surgeries (MIGSs) when combined with cataract surgery in patients with primary open-angle glaucoma (POAG). Methods: Treatment effects, as measured by the 1-year reduction in intraocular pressure (IOP), were estimated with an adjusted indirect treatment comparison. Evidence from randomized clinical trials was identified for four different MIGS methods. A disease-transition model was developed by capturing clinically relevant POAG stages and the expected natural disease evolution. Outcomes of the disease-transition model were the comparative utility [quality-adjusted life years (QALYs)], cost and cost-utility of included strategies in a lifetime horizon. Results: Estimated 1-year IOP reductions were: cataract surgery - 2.05 mmHg (95% CI - 3.38; - 0.72), one trabecular micro-bypass stent - 3.15 mmHg (95% CI - 5.66; - 0.64), two trabecular micro-bypass stents - 4.85 mmHg (95% CI - 7.71; - 1.99) and intracanalicular scaffold - 2.25 mmHg (95% CI - 4.87; 0.37). Discounted outcomes from the disease-transition model appraised the strategy of two trabecular micro-bypass stents with cataract surgery in the moderate POAG stage as the one providing the greatest added value, with 10,955€ per additional QALY. Improved outcomes were seen when assessing MIGS in the moderate POAG stage. Conclusions: When indirectly comparing alternative MIGS methods combined with cataract ....

Medienart:

E-Book

Erscheinungsjahr:

March 2020

Erschienen:

Greifswald: March 2020

Weitere Ausgaben:

Erscheint auch als Druck-Ausgabe: Comparative efficacy and Long-Term Cost-Utility of combined cataract and minimally invasive Glaucoma surgery in German patients with Primary Open-Angle Glaucoma

Sprache:

Englisch

Beteiligte Personen:

Bartelt-Hofer, Jose [VerfasserIn]
Fleßa, Steffen, 1966- [Akademische/r BetreuerIn]
Ried, Walter, 1959- [Akademische/r BetreuerIn]

Hochschulschrift:

Dissertation, Rechts- und Staatswissenschaftliche Fakultät der Universität Greifswald, 2020

Links:

nbn-resolving.org
d-nb.info
epub.ub.uni-greifswald.de [kostenfrei]
Volltext [kostenfrei]

BKL:

44.95 / Augenheilkunde

44.05 / Gesundheitsökonomie

Themen:

Deutschland
Gesundheitsökonomie
Glaukom
Hochschulschrift
Kosten-Nutzen-Analyse
Minimal-invasive Chirurgie
Staroperation
Weitwinkelglaukom

Anmerkungen:

Literaturverzeichnis: Seite 83-93

Umfang:

1 Online-Ressource (PDF-Datei: 152 Seiten, 10429 Kilobyte) ; Illustrationen, Diagramme (teilweise farbig)

Weitere IDs:

urn:nbn:de:gbv:9-opus-40897

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

1741811449

Zugang & Verfügbarkeit

Zugehörige Publikationen/Bände

    Haven't found what you're looking for?