Details der Publikation - Radiation-induced acute toxicities after image-guided intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for patients with spinal metastases (IRON-1 trial)

Radiation-induced acute toxicities after image-guided intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for patients with spinal metastases (IRON-1 trial) : first results of a randomized controlled trial = Radiogene Akuttoxizität nach bildgeführter intensitätsmodulierter Strahlentherapie versus dreidimensionaler konformaler Strahlentherapie bei Patienten mit Wirbelkörpermetastasen (IRON-1 trial) / Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Thomas Bruckner, Tilman Bostel, Stefan Ezechiel Welte, Eric Tonndorf-Martini, Rami El Shafie, Nils Henrik Nicolay, Jürgen Debus, Harald Rief

PURPOSE: Radiation therapy (RT) provides an important treatment approach in the palliative care of vertebral metastases, but radiation-induced toxicities in patients with advanced disease and low performance status can have substantial implications for quality of life. Herein, we prospectively compared toxicity profiles of intensity-modulated radiotherapy (IMRT) vs. conventional three-dimensional conformal radiotherapy (3DCRT). - METHODS: This was a prospective randomized monocentric explorative pilot trial to compare radiation-induced toxicity between IMRT and 3DCRT for patients with spinal metastases. A total of 60 patients were randomized between November 2016 and May 2017. In both cohorts, RT was delivered in 10 fractions of 3Gy each. The primary endpoint was radiation-induced toxicity at 3 months. - RESULTS: Median follow-up was 4.3 months. Two patients suffered from grade 3 acute toxicities in the IMRT arm, along with 1 patient in the 3DCRT group. At 12 weeks after treatment (t2), 1 patient reported grade 3 toxicity in the IMRT arm vs. 4 patients in the 3DCRT group. No grade 4 or 5 adverse events occurred in either group. In the IMRT arm, the most common side effects by the end of irradiation (t1) were grade 1-2 xerostomia and nausea in 8 patients each (29.6%), and dyspnea in 7 patients (25.9%). In the 3DCRT group, the most frequent adverse events (t1) were similar: grade 1-2 xerostomia (n= 10, 35.7%), esophagitis (n= 10, 35.8%), nausea (n= 10, 35.8%), and dyspnea (n= 5, 17.9%). - CONCLUSION: This is the first randomized trial to evaluate radiation-induced toxicities after IMRT versus 3DCRT in patients with vertebral metastases. This trial demonstrated an additional improvement for IMRT in terms of acute side effects, although longer follow-up is required to further ascertain other endpoints..

Medienart:	E-Artikel

Erscheinungsjahr:	05 July 2018 2018
Erschienen:	05 July 2018

Enthalten in:	Zur Gesamtaufnahme - volume:194
Enthalten in:	Strahlentherapie und Onkologie - 194(2018), 10, Seite 911-920

Sprache:	Englisch

Weiterer Titel:	Radiogene Akuttoxizität nach bildgeführter intensitätsmodulierter Strahlentherapie versus dreidimensionaler konformaler Strahlentherapie bei Patienten mit Wirbelkörpermetastasen (IRON-1 trial)

Beteiligte Personen:	Sprave, Tetyana, 1978- [VerfasserIn] Verma, Vivek [VerfasserIn] Förster, Robert, 1984- [VerfasserIn] Schlampp, Ingmar, 1982- [VerfasserIn] Bruckner, Thomas, 1956- [VerfasserIn] Bostel, Tilman, 1978- [VerfasserIn] Welte, Stefan Ezechiel, 1979- [VerfasserIn] Tonndorf-Martini, Eric [VerfasserIn] El-Shafie, Rami, 1989- [VerfasserIn] Nicolay, Nils [VerfasserIn] Debus, Jürgen, 1964- [VerfasserIn] Rief, Harald [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Aged Cohort Studies Dose Fractionation, Radiation Female Follow-Up Studies Humans Intensity-modulated radiotherapy Male Middle Aged Palliative Care Palliative radiotherapy Pilot Projects Prospective Studies Radiation Injuries Radiotherapy, Conformal Radiotherapy, Image-Guided Radiotherapy, Intensity-Modulated Side effects Spinal Neoplasms Spinal bone metastases Toxicity

Anmerkungen:	Gesehen am 02.04.2020

Umfang:	10

doi:	10.1007/s00066-018-1333-z

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1693839288

Internformat


LEADER	01000caa a2200265 4500
001	1693839288
003	DE-627
005	20240405193211.0
007	cr uuu---uuuuu
008	200402s2018 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1007/s00066-018-1333-z \|2 doi
035			\|a (DE-627)1693839288
035			\|a (DE-599)KXP1693839288
035			\|a (OCoLC)1341313311
040			\|a DE-627 \|b ger \|c DE-627 \|e rda
041			\|a eng
100	1		\|a Sprave, Tetyana \|d 1978- \|e verfasserin \|0 (DE-588)105090592X \|0 (DE-627)78527216X \|0 (DE-576)405300115 \|4 aut
245	1	0	\|a Radiation-induced acute toxicities after image-guided intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for patients with spinal metastases (IRON-1 trial) \|b first results of a randomized controlled trial = Radiogene Akuttoxizität nach bildgeführter intensitätsmodulierter Strahlentherapie versus dreidimensionaler konformaler Strahlentherapie bei Patienten mit Wirbelkörpermetastasen (IRON-1 trial) \|c Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Thomas Bruckner, Tilman Bostel, Stefan Ezechiel Welte, Eric Tonndorf-Martini, Rami El Shafie, Nils Henrik Nicolay, Jürgen Debus, Harald Rief
246	3	1	\|a Radiogene Akuttoxizität nach bildgeführter intensitätsmodulierter Strahlentherapie versus dreidimensionaler konformaler Strahlentherapie bei Patienten mit Wirbelkörpermetastasen (IRON-1 trial)
264		1	\|c 05 July 2018
300			\|a 10
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
500			\|a Gesehen am 02.04.2020
520			\|a PURPOSE: Radiation therapy (RT) provides an important treatment approach in the palliative care of vertebral metastases, but radiation-induced toxicities in patients with advanced disease and low performance status can have substantial implications for quality of life. Herein, we prospectively compared toxicity profiles of intensity-modulated radiotherapy (IMRT) vs. conventional three-dimensional conformal radiotherapy (3DCRT). - METHODS: This was a prospective randomized monocentric explorative pilot trial to compare radiation-induced toxicity between IMRT and 3DCRT for patients with spinal metastases. A total of 60 patients were randomized between November 2016 and May 2017. In both cohorts, RT was delivered in 10 fractions of 3Gy each. The primary endpoint was radiation-induced toxicity at 3 months. - RESULTS: Median follow-up was 4.3 months. Two patients suffered from grade 3 acute toxicities in the IMRT arm, along with 1 patient in the 3DCRT group. At 12 weeks after treatment (t2), 1 patient reported grade 3 toxicity in the IMRT arm vs. 4 patients in the 3DCRT group. No grade 4 or 5 adverse events occurred in either group. In the IMRT arm, the most common side effects by the end of irradiation (t1) were grade 1-2 xerostomia and nausea in 8 patients each (29.6%), and dyspnea in 7 patients (25.9%). In the 3DCRT group, the most frequent adverse events (t1) were similar: grade 1-2 xerostomia (n= 10, 35.7%), esophagitis (n= 10, 35.8%), nausea (n= 10, 35.8%), and dyspnea (n= 5, 17.9%). - CONCLUSION: This is the first randomized trial to evaluate radiation-induced toxicities after IMRT versus 3DCRT in patients with vertebral metastases. This trial demonstrated an additional improvement for IMRT in terms of acute side effects, although longer follow-up is required to further ascertain other endpoints.
650		4	\|a Aged
650		4	\|a Cohort Studies
650		4	\|a Dose Fractionation, Radiation
650		4	\|a Female
650		4	\|a Follow-Up Studies
650		4	\|a Humans
650		4	\|a Intensity-modulated radiotherapy
650		4	\|a Male
650		4	\|a Middle Aged
650		4	\|a Palliative Care
650		4	\|a Palliative radiotherapy
650		4	\|a Pilot Projects
650		4	\|a Prospective Studies
650		4	\|a Radiation Injuries
650		4	\|a Radiotherapy, Conformal
650		4	\|a Radiotherapy, Image-Guided
650		4	\|a Radiotherapy, Intensity-Modulated
650		4	\|a Side effects
650		4	\|a Spinal bone metastases
650		4	\|a Spinal Neoplasms
650		4	\|a Toxicity
700	1		\|a Verma, Vivek \|e verfasserin \|4 aut
700	1		\|a Förster, Robert \|d 1984- \|e verfasserin \|0 (DE-588)1063692660 \|0 (DE-627)812495810 \|0 (DE-576)422845159 \|4 aut
700	1		\|a Schlampp, Ingmar \|d 1982- \|e verfasserin \|0 (DE-588)1014278430 \|0 (DE-627)705203255 \|0 (DE-576)348136986 \|4 aut
700	1		\|a Bruckner, Thomas \|d 1956- \|e verfasserin \|0 (DE-588)136046215 \|0 (DE-627)574429298 \|0 (DE-576)300798768 \|4 aut
700	1		\|a Bostel, Tilman \|d 1978- \|e verfasserin \|0 (DE-588)101379124X \|0 (DE-627)664944183 \|0 (DE-576)347666809 \|4 aut
700	1		\|a Welte, Stefan Ezechiel \|d 1979- \|e verfasserin \|0 (DE-588)103362599X \|0 (DE-627)742088715 \|0 (DE-576)381245284 \|4 aut
700	1		\|a Tonndorf-Martini, Eric \|e verfasserin \|0 (DE-588)1107564891 \|0 (DE-627)863513875 \|0 (DE-576)475080882 \|4 aut
700	1		\|a El-Shafie, Rami \|d 1989- \|e verfasserin \|0 (DE-588)110057378X \|0 (DE-627)859521427 \|0 (DE-576)469743859 \|4 aut
700	1		\|a Nicolay, Nils \|e verfasserin \|0 (DE-588)136200834 \|0 (DE-627)694181277 \|0 (DE-576)279367880 \|4 aut
700	1		\|a Debus, Jürgen \|d 1964- \|e verfasserin \|0 (DE-588)1022671421 \|0 (DE-627)717025780 \|0 (DE-576)365774944 \|4 aut
700	1		\|a Rief, Harald \|e verfasserin \|0 (DE-588)1056885270 \|0 (DE-627)79417888X \|0 (DE-576)412866978 \|4 aut
773	0	8	\|i Enthalten in \|t Strahlentherapie und Onkologie \|d Berlin : Springer Medizin, 1997 \|g 194(2018), 10, Seite 911-920 \|h Online-Ressource \|w (DE-627)312407866 \|w (DE-600)2003907-4 \|w (DE-576)090884809 \|x 1439-099X \|7 nnns
773	1	8	\|g volume:194 \|g year:2018 \|g number:10 \|g pages:911-920 \|g extent:10
856	4	0	\|u https://doi.org/10.1007/s00066-018-1333-z \|x Verlag \|x Resolving-System \|z lizenzpflichtig \|3 Volltext
912			\|a GBV_USEFLAG_U
912			\|a GBV_ILN_2013
912			\|a ISIL_DE-16-250
912			\|a SYSFLAG_1
912			\|a GBV_KXP
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_267
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
912			\|a GBV_ILN_711
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2188
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_2548
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4277
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 194 \|j 2018 \|e 10 \|h 911-920 \|g 10
980			\|2 2013 \|1 01 \|x DE-16-250 \|b 3617689167 \|c 00 \|f --%%-- \|d --%%-- \|e --%%-- \|j --%%-- \|y l01 \|z 02-04-20
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 00 \|s s \|a hd2018
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 01 \|s s \|0 (DE-627)1410508463 \|a wissenschaftlicher Artikel (Zeitschrift)
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 02 \|s s \|a per_12
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 03 \|s s \|a s_10
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 04 \|s p \|0 (DE-627)155567464X \|a Sprave, Tetyana
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 04 \|s k \|0 (DE-627)1416741399 \|a Radiologische Universitätsklinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 04 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 04 \|s s \|a pos_1
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 05 \|s p \|0 (DE-627)1492845175 \|a Förster, Robert
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 05 \|s k \|0 (DE-627)1416741399 \|a Radiologische Universitätsklinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 05 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 05 \|s s \|a pos_3
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 06 \|s p \|0 (DE-627)1484537726 \|a Schlampp, Ingmar
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 06 \|s k \|0 (DE-627)1416741399 \|a Radiologische Universitätsklinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 06 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 06 \|s s \|a pos_4
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 07 \|s p \|0 (DE-627)144822702X \|a Bruckner, Thomas
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 07 \|s k \|0 (DE-627)1416741593 \|a Institut für Medizinische Biometrie und Informatik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 07 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 07 \|s s \|a pos_5
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 08 \|s p \|0 (DE-627)1479913057 \|a Bostel, Tilman
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 08 \|s k \|0 (DE-627)1416741399 \|a Radiologische Universitätsklinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 08 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 08 \|s s \|a pos_6
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 09 \|s p \|0 (DE-627)1504212991 \|a Welte, Stefan Ezechiel
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 09 \|s k \|0 (DE-627)1416741399 \|a Radiologische Universitätsklinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 09 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 09 \|s s \|a pos_7
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 10 \|s p \|0 (DE-627)1545085765 \|a Tonndorf-Martini, Eric
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 10 \|s k \|0 (DE-627)1416741399 \|a Radiologische Universitätsklinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 10 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 10 \|s s \|a pos_8
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s p \|0 (DE-627)1479913405 \|a Nicolay, Nils
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s k \|0 (DE-627)1416741399 \|a Radiologische Universitätsklinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s s \|a pos_10
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s p \|0 (DE-627)1539724123 \|a El-Shafie, Rami
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s k \|0 (DE-627)1416741399 \|a Radiologische Universitätsklinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s s \|a pos_9
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 12 \|s p \|0 (DE-627)1435777980 \|a Debus, Jürgen
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 12 \|s k \|0 (DE-627)1416741399 \|a Radiologische Universitätsklinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 12 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 12 \|s s \|a pos_11
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 13 \|s p \|0 (DE-627)1482867249 \|a Rief, Harald
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 13 \|s k \|0 (DE-627)1416741399 \|a Radiologische Universitätsklinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 13 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 13 \|s s \|a pos_12

Zugang & Verfügbarkeit

Zugehörige Publikationen/Bände