Accurate Results in the Clinical Laboratory : a Guide to Error Detection and Correction / edited by Amitava Dasgupta, Jorge L. Sepulveda

I: Sources of errors in clinical laboratories: an overview. Variation, errors, and quality in the clinical laboratory -- Errors in patient preparation, specimen collection, anticoagulant and preservative use: how to avoid such pre-analytical errors -- Sample processing and specimen misidentification issues: major sources of pre-analytical errors -- Effect of patient-related factors on clinical laboratory test results -- Interferences of hemolysis, lipemia and high bilirubin on laboratory tests -- Immunoassay design -- Overview of other sources of interferences in immunoassays: prozone effect and interferences from heterophilic antibodies and autoantibodies -- Biotin interference in clinical laboratory tests: sporadic problem or a serious clinical issue? -- II: Sources of errors in clinical chemistry laboratory. Challenges in routine clinical chemistry testing analysis of small molecules -- Challenges in routine clinical chemistry analysis: proteins and enzymes -- Challenges in endocrinology testing -- Pitfalls in testing for common tumor markers -- III: Sources of errors in therapeutic drug monitoring and toxicology. Issues of interferences in therapeutic drug monitoring -- Limitations of immunoassays for screening of drugs of abuse in urine: issues of false positive and false negative results -- Challenges in confirmation testing for drugs of abuse -- Issues of false negative results in toxicology: difficult in detecting certain drugs and issues with detection of synthetic cathinone (bath salts), synthetic cannabinoids (spice), and other new psychoactive substances -- Ethanol determination using automated analyzers: limitations and pitfalls -- IV: Herbal medicines and laboratory testings. Effects of herbal supplements on clinical laboratory test results -- V: Sources of errors in immunology laboratory. Critical issues in hemoglobinopathy detection and serology testing for HIV and hepatitis infections -- Sources of errors in immunology and serology testing -- VI: Sources of errors in molecular, genetic and related testings. Sources of error in molecular diagnostic analyses -- Molecular testing for targeted therapies and pharmacogenomics -- Challenges and sources of inaccuracy in biochemical genetics testing -- VII: Sources of errors in microbiology testings. Sources of pre-analytical, analytical and post-analytical errors in the microbiology laboratory -- VIII: Sources of errors in hematology and coagulation testings. Sources of errors in hematology testing -- Sources of errors in coagulation testing -- Sources of errors in flow cytometry -- IX: Sources of errors in transfusion medicine. Interferences in blood bank testing -- Errors and adverse effects of blood transfusion -- X: Sources of errors in point of care testing. Methodological issues in point of care testing devices -- Special concern: sources of inaccuracy in breath alcohol analysis..

"Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, Second Edition, provides a comprehensive review of the factors leading to errors in all areas of clinical laboratory testing. This trusted guide addresses interference issues in all laboratory tests, including patient epigenetics, processes of specimen collection, enzymes and biomarkers"--Publisher's description.

Medienart:	E-Book

Erscheinungsjahr:	2019
Erschienen:	Amsterdam: Elsevier ; 2019
Ausgabe:	2nd ed

Sprache:	Englisch

Beteiligte Personen:	Dasgupta, Amitava, 1958- [Sonstige Person] Sepulveda, Jorge L. [Sonstige Person]

Links:	www.sciencedirect.com [lizenzpflichtig]

ISBN:	978-0-12-813777-2 0-12-813777-0

Nlm:

QY 25

Themen:

Clinical Laboratory Techniques Diagnosis, Laboratory Diagnosis, Laboratory ; Quality control Diagnostic Errors Diagnostic Tests, Routine Diagnostics biologiques Diagnostics biologiques - Qualit�e - Contr�ole Electronic books Evidence-based medicine Laboratories M�edecine - Laboratoires M�edecine - Laboratoires - Qualit�e - Contr�ole Medical Laboratory Science Medical laboratories Medical laboratories ; Quality control Qualit�e - Contr�ole Quality Control Quality control

Anmerkungen:	Includes index

Umfang:	1 Online-Ressource (512 pages)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1689042974