Loomis' essentials of toxicology / A. Wallace Hayes (University of South Florida College of Public Health, Tampa, Florida, Institute for Integrative Toxicology, Michigan State University, East Lansing, MI), Tao Wang (Coherus BioSciences, Redwood City, CA), Darlene Dixon (National Institute of Environmental Health Sciences/National Toxicology Program, Research Triangle Park, NC)

Front Cover -- Loomis's Essentials of Toxicology -- Copyright -- Dedication -- Contents -- Preface -- Chapter 1: Introduction, scope, and principles -- History -- Scope of modern toxicology -- Environmental toxicology -- Economic toxicology -- Medical toxicology -- Fundamental principles in toxicology -- Chapter 2: Dose and dose-response relationships in toxicology -- Dose -- Internal exposure versus external dose -- Biologic variation -- Frequency distribution in response -- Cumulative dose-response -- Relative toxicity and traditional LD50 -- Safety versus toxicity -- Hypersensitivity and hyposensitivity to toxicant exposures -- Nonlinear dose-response curves -- Reference doses used in risk assessment and regulatory toxicology -- Chapter 3: Biologic factors that influence toxicity -- Absorption and translocation of chemicals -- Reserve functional capacity -- Accumulation and storage of chemicals in the organism -- Tolerance -- Chapter 4: Chemical factors that influence toxicity -- Nonspecific chemical action -- Selective chemical action -- Target concepts in toxicity -- Effect of ionization and lipid solubility on translocation of chemicals -- Effects of biotransformation on mechanisms of toxicity -- Inhibition of biotransformation enzymes -- Induction of biotransformation enzymes -- Chapter 5: Influence of route of administration on systemic toxicity -- Percutaneous route -- Inhalation route -- Oral route -- Parenteral routes -- Chapter 6: Genetic factors that influence toxicity -- The genetic mechanism -- Chemicals as mutagens -- Principles of genetic-induced chemical toxicity -- Discovery and classification of genetic-induced chemical toxicity -- Genetic factors in accumulation of chemicals -- Genetic factors in prolongation of action of chemicals -- Genetic factors in increased sensitivity to chemicals -- Drug-sensitive hemoglobins..

Medienart:	E-Book

Erscheinungsjahr:	[2020] ©2020
Erschienen:	London San Diego: Elsevier, Academic Press ; 2020 ©2020
Ausgabe:	Fifth edition

Weitere Ausgaben:	Erscheint auch als Druck-Ausgabe: Loomis' essentials of toxicology

Sprache:	Englisch

Beteiligte Personen:	Hayes, Andrew Wallace, 1939- [VerfasserIn] Wang, Tao [VerfasserIn] Dixon, Darlene [VerfasserIn] Loomis, Ted Albert, 1917-2016 [Sonstige Person]

Links:	Volltext [lizenzpflichtig]

ISBN:	978-0-12-815922-4

Themen:	Electronic books Toxicology

Anmerkungen:	Description based on publisher supplied metadata and other sources

Umfang:	1 Online-Ressource (x, 260 Seiten)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1683244532