Natural products in medicinal chemistry / edited by Stephen Hanessian
Natural products as drugs and leads to drugs: an introduction and perspectives as of the end of 2012 -- Natural product-derived and natural product-inspired compound collections -- Chemistry and biology of epothilones -- Taxol, taxoids, and related taxanes -- Camptothecin and analogs -- A short history of the discovery and development of naltrexone and other morphine derivatives -- Lincosamide antibacterials -- Platensimycin and platencin -- From natural product to new diabetes therapy: phlorizin and the discovery of SGLT2 inhibitor clinical candidates -- Aeruginosins as thrombin inhibitors -- Macrolides and antifungals via biotransformation -- Unnatural nucleoside analogs for antisense therapy -- Hybrid natural products -- Rethinking the role of natural products: function-oriented synthesis bryostatin, and bryologs -- Cyclopamine and congeners -- Hybrids, congeners, mimics and constrained variants spanning 30 years of natural products chemistry: a personal retrospective..
The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 15 highly informative chapters. Using well-documented case studies from drug development projects over the past decade, this handbook and ready reference demonstrates the current importance and future potential of natural products as drug precursors, highlighting the lessons learned and pointing to future directions in the field. The examples are carefully chosen so as to represent a wide range of chemical structures as well a.
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
[2014] |
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| Erschienen: |
Weinheim: Wiley-VCH ; 2014 |
| Ausgabe: |
First edition |
| Reihe: |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hanessian, Stephen [HerausgeberIn] |
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| Links: |
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| ISBN: |
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| Themen: |
Biological Factors |
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| Anmerkungen: |
Includes bibliographical references at the end of each chapters and index |
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| Umfang: |
1 Online-Ressource (xxi, 630 pages) |
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| doi: |
10.1002/9783527676545 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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1679579908 |
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| 520 | |a The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 15 highly informative chapters. Using well-documented case studies from drug development projects over the past decade, this handbook and ready reference demonstrates the current importance and future potential of natural products as drug precursors, highlighting the lessons learned and pointing to future directions in the field. The examples are carefully chosen so as to represent a wide range of chemical structures as well a | ||
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