Pharmaceutical inhalation aerosol technology / [edited by] Anthony J. Hickey, Sandro R. da Rocha.

1. Introduction -- Section I Discovery (pharmacology/physiology/anatomy, etc) -- 2. Physiology of the Airways -- 3. Drug Targeting to the Lung: Chemical and Biochemical Considerations -- Section II Aerosol Critical Attributes (aerodynamic behavior, lung deposition, and clearance) -- 4. Aerosol Physics and Lung Deposition Modelling -- 5. Practical Aspects of Imaging Techniques Employed to Study Aerosol Deposition and Clearance -- 6. Pharmacokinetics and Pharmacodynamics of Drugs Delivered to the Lung -- Section III Active Pharmaceutical -- Ingredient/Drug Product Manufacturing -- 7 Small Molecules: Process Intensification and Continuous Synthesis -- 8 Biologic Drug Substance and Drug Product Manufacture -- 9 Scale-Up Considerations for Orally Inhaled Drug Products -- 10 Quality by Control -- Section IV Particle Engineering/Processing (milling/blending, spray drying, supercritical fluid, nano, etc.) -- 11. Milling and Blending: Producing the Right Particles and Blend Characteristics for Dry Powder Inhalation -- 12. Engineering Stable Spray Dried Biologic Powder for Inhalation -- 13 Supercritical Fluid Manufacture -- 14 Particle Engineering Technology for Inhaled Therapies -- Section V Drug Product Formulation -- 15 Emerging Pulmonary Delivery Strategies in Gene Therapy: State of the Art and Future Considerations -- 16 Genome Editing for Genetic Lung Diseases -- 17 Inhalation Drug Products Containing Nanomaterials -- Section VI Devices (design and performance) -- 18. Pressurized Metered-Dose Inhalers -- 19. Dry Powder Inhalation -- 20. Nebulisers -- 21. Soft Mist Sprays -- Section VII Drug Product Testing (physico-chemical properties, aerodynamic particle size, delivered dose, etc.) -- 22 Quality by Design Considerations -- 23 Solid State Testing of Inhaled Formulations -- 24 Aerodynamic Particle Size Testing -- Section VIII Regulatory Considerations (CMC) -- 25. Scanning the Intricate Regulatory Landscape and Trying to Peek Over the Horizon -- 26. Pharmacopeial and Regulatory Guidances on Product Quality and Performance -- 27. The European Union Regulatory Scene -- Section IX Preclinical Testing (dosing for cells and animals) -- 28. Cell- and Tissue-Based (Reconstituted) 2D In Vitro Models to Study Drug Transport Processes across the Air-Blood Barrier -- 29. 3D In Vitro/Ex Vivo Systems -- 30. Preclinical Models for Pulmonary Drug Delivery -- Section X Clinical Testing (concepts of bioequivalence) -- 31. Bioequivalence of Orally-Inhaled Drug Products: Challenges and Opportunities -- 32. General Conclusions -- Index..

Medienart:	E-Book

Erscheinungsjahr:	[2019]
Erschienen:	Boca Raton, Florida: CRC Press, ; 2019
Ausgabe:	Third edition.

Reihe:	Drugs and the pharmaceutical sciences

Sprache:	Englisch

Beteiligte Personen:	Hickey, Anthony J., 1955- [HerausgeberIn]

Links:	www.taylorfrancis.com [lizenzpflichtig]

ISBN:	978-0-429-05520-1 0-429-05520-X 978-0-429-61956-4 0-429-61956-1 978-0-429-62171-0 0-429-62171-X 978-0-429-61741-6 0-429-61741-0

Themen:	Administration, Inhalation Aerosol therapy Aerosols Drug Delivery Systems Drug Development Electronic books Lung MEDICAL / Pharmacology Pharmaceutical technology Technology, Pharmaceutical

Umfang:	1 online resource ; illustrations.

doi:	10.1201/9780429055201.

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1678226440