Targeting the DNA Damage Response for Anti-Cancer Therapy.
Intro -- Contents -- Contributors -- Chapter 1: Targeting DNA Repair in Anti-Cancer Treatments -- 1.1 PARP Inhibitors to Targeted DNA Repair -- 1.2 Limits to the Synthetic Lethal Approach of Targeting Cancer -- 1.3 Combining Chemotherapy Treatment with DNA Repair Inhibitors -- 1.4 Exploiting the Inherent High Level of DNA Damage in Cancers -- Replication Stress -- 1.5 Future Challenges in Targeting DNA Repair for Cancer Treatments -- References -- Chapter 2: The DNA Damage Response: Roles in Cancer Etiology and Treatment -- 2.1 Problems Associated with Current Chemo- and Radiotherapies -- 2.2 The Promise of Targeted Cancer Treatment -- 2.3 The DNA Damage Response (DDR) -- 2.4 Oncogenes Cause Genomic Instability and DDR Activation -- 2.5 Tumor Suppression Through Checkpoint Activation and DNA Repair -- 2.6 Targeting HR and ATM Deficiencies with PARP and DNA-PK Inhibition -- 2.7 Targeting Oncogenic Stress, ATM-p53 Loss, and HR Deficiency with ATR, CHK1 and WEE1 Inhibitors -- 2.8 Future Areas of Research -- References -- Chapter 3: Control of DNA Replication by ATR -- 3.1 Introduction -- 3.2 ATR Is a PI3K-Related Kinase (PIKK) -- 3.3 ATR Activation -- 3.3.1 First Step: ssDNA Recruits the ATR-ATRIP Complex -- 3.3.2 Second Step: TOPBP1 Is Necessary for Full Activation of ATR-ATRIP -- 3.3.3 Third Step: CLASPIN Is an Adaptor for CHK1 Phosphorylation -- 3.3.4 Fine Tuning: Post-Translational Modifications Regulate the Activation of ATR-ATRIP -- 3.4 Local, Regional and Global Checkpoint Functions of ATR-ATRIP -- 3.4.1 Local Action of ATR-ATRIP on Replication Forks -- 3.4.2 Regional Modulation of Replication Factories -- 3.4.3 Global Regulation of DNA Replication and the Cell Cycle -- 3.5 Functions of ATR and CHK1 in Cancer -- 3.5.1 ATR and CHK1 Are Essential -- 3.5.2 Malignant Transformation Generates Replication Stress..
| Medienart: |
E-Book |
|---|
| Erscheinungsjahr: |
2018 ©2018 |
|---|---|
| Erschienen: |
Cham: Humana Press ; 2018 ©2018 |
| Reihe: |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Pollard, John [VerfasserIn] |
|---|
| Links: |
ebookcentral.proquest.com [lizenzpflichtig] |
|---|
| ISBN: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Description based on publisher supplied metadata and other sources |
|---|
| Umfang: |
1 online resource (402 pages) |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
167322346X |
|---|
| LEADER | 01000cam a22002652 4500 | ||
|---|---|---|---|
| 001 | 167322346X | ||
| 003 | DE-627 | ||
| 005 | 20230428171319.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190830s2018 xx |||||o 00| ||eng c | ||
| 020 | |a 9783319758367 |9 978-3-319-75836-7 | ||
| 035 | |a (DE-627)167322346X | ||
| 035 | |a (DE-599)KEP037433393 | ||
| 035 | |a (EBL)EBL5403656 | ||
| 035 | |a (EBC)EBC5403656 | ||
| 035 | |a (EBP)037433393 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 082 | 0 | |a 616.99406 | |
| 100 | 1 | |a Pollard, John |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Targeting the DNA Damage Response for Anti-Cancer Therapy. |
| 264 | 1 | |a Cham |b Humana Press |c 2018 | |
| 264 | 4 | |c ©2018 | |
| 300 | |a 1 online resource (402 pages) | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 490 | 0 | |a Cancer Drug Discovery and Development Ser. | |
| 500 | |a Description based on publisher supplied metadata and other sources | ||
| 520 | |a Intro -- Contents -- Contributors -- Chapter 1: Targeting DNA Repair in Anti-Cancer Treatments -- 1.1 PARP Inhibitors to Targeted DNA Repair -- 1.2 Limits to the Synthetic Lethal Approach of Targeting Cancer -- 1.3 Combining Chemotherapy Treatment with DNA Repair Inhibitors -- 1.4 Exploiting the Inherent High Level of DNA Damage in Cancers -- Replication Stress -- 1.5 Future Challenges in Targeting DNA Repair for Cancer Treatments -- References -- Chapter 2: The DNA Damage Response: Roles in Cancer Etiology and Treatment -- 2.1 Problems Associated with Current Chemo- and Radiotherapies -- 2.2 The Promise of Targeted Cancer Treatment -- 2.3 The DNA Damage Response (DDR) -- 2.4 Oncogenes Cause Genomic Instability and DDR Activation -- 2.5 Tumor Suppression Through Checkpoint Activation and DNA Repair -- 2.6 Targeting HR and ATM Deficiencies with PARP and DNA-PK Inhibition -- 2.7 Targeting Oncogenic Stress, ATM-p53 Loss, and HR Deficiency with ATR, CHK1 and WEE1 Inhibitors -- 2.8 Future Areas of Research -- References -- Chapter 3: Control of DNA Replication by ATR -- 3.1 Introduction -- 3.2 ATR Is a PI3K-Related Kinase (PIKK) -- 3.3 ATR Activation -- 3.3.1 First Step: ssDNA Recruits the ATR-ATRIP Complex -- 3.3.2 Second Step: TOPBP1 Is Necessary for Full Activation of ATR-ATRIP -- 3.3.3 Third Step: CLASPIN Is an Adaptor for CHK1 Phosphorylation -- 3.3.4 Fine Tuning: Post-Translational Modifications Regulate the Activation of ATR-ATRIP -- 3.4 Local, Regional and Global Checkpoint Functions of ATR-ATRIP -- 3.4.1 Local Action of ATR-ATRIP on Replication Forks -- 3.4.2 Regional Modulation of Replication Factories -- 3.4.3 Global Regulation of DNA Replication and the Cell Cycle -- 3.5 Functions of ATR and CHK1 in Cancer -- 3.5.1 ATR and CHK1 Are Essential -- 3.5.2 Malignant Transformation Generates Replication Stress. | ||
| 650 | 4 | |a Cancer-Treatment-Genetic aspects | |
| 650 | 4 | |a Electronic books | |
| 700 | 1 | |a Curtin, Nicola |e mitwirkender |4 ctb | |
| 776 | 1 | |z 9783319758343 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783319758343 |
| 856 | 4 | 0 | |u https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=5403656 |m X:EBC |x Aggregator |z lizenzpflichtig |
| 912 | |a ZDB-30-PQE | ||
| 912 | |a GBV_ILN_206 | ||
| 912 | |a ISIL_DE-Brg3 | ||
| 912 | |a SYSFLAG_1 | ||
| 912 | |a GBV_KXP | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a GBV_ILN_2021 | ||
| 912 | |a ISIL_DE-289 | ||
| 951 | |a BO | ||
| 953 | |2 045F |a 616.99406 | ||
| 980 | |2 206 |1 01 |x 3350 |b 3510029380 |c 00 |f --%%-- |d Online-Ressource |e g |j --%%-- |h OLR-EBL |k If you are a ThHF affiliate and the E-Book is not fully accessible, please send us a purchase or short time loan request. All others: Inter-library loans and guest access on campus premises is not possible. |y zh |z 31-08-19 | ||
| 980 | |2 2021 |1 01 |x DE-289 |b 3844772405 |c 00 |f --%%-- |d --%%-- |e --%%-- |j n |y l01 |z 29-01-21 | ||
| 981 | |2 206 |1 01 |x 3350 |y Full Text only for ThHF affiliates |r https://thh-friedensau.idm.oclc.org/login?url=http://ebookcentral.proquest.com/lib/thhfriedensau/detail.action?docID=5403656 | ||
| 981 | |2 2021 |1 01 |x DE-289 |r https://ebookcentral.proquest.com/lib/kiz-uniulm/detail.action?docID=5403656 | ||
| 995 | |2 206 |1 01 |x 3350 |a OLR-EBL | ||