Untersuchungen zum Einfluss des Mas-Rezeptors auf die Funktion von β-Zellen / vorgelegt von Anika Sahr ; 1. Gutachter: Prof. Dr. Reinhard Walther, 2. Gutachter: PD Dr. Matthias Elsner
B-Zelle, Diabetes mellitus, Insulin, Insulinsekretion, Langerhans-Inseln, Renin-Angiotensin-System, Mas-Rezeptor.
The renin-angiotensin system (RAS) is a hormonal system that can influence diverse physiological processes by binding of angiotensin peptides to their specific receptors. In recent years, the alternative angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor axis of the RAS has come into focus of research due to its protective role in pathophysiological states. The relevance of the local ACE2/Ang-(1-7)/Mas axis for the function of islets of Langerhans, especially with regard to the production and secretion of insulin, has been little investigated so far. Therefore, the aim of the present work was to determine the influence of the Mas receptor and its ligand Ang-(1-7) on β-cell function and to elucidate responsible molecular mechanisms. For this purpose, isolated islets from of wild-type (WT) and Mas-deficient mice were used, which were initially characterised comprehensively with regard to the expression of components of the ACE2/Ang-(1-7)/Mas axis. The influence of Ang-(1-7) and Ang-(1-7) antagonists D-Ala7-Ang-(1-7) (A779) and D-Pro7-Ang-(1-7) (D-Pro) on insulin production and glucose-stimulated insulin secretion (GSIS) was then determined. Isolated islets of Mas-deficient mice showed a significantly reduced GSIS compared to WT islets. Accordingly, incubation of WT islets with A779 and D-Pro resulted in a reduced GSIS, whereas the Mas-ligand Ang-(1-7) was able to significantly increase GSIS. These findings underline the relevance of the ACE2/Ang-(1-7) ....
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
September 2018 |
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| Erschienen: |
Greifswald: September 2018 |
| Weitere Ausgaben: |
Erscheint auch als Druck-Ausgabe: Untersuchungen zum Einfluss des Mas-Rezeptors auf die Funktion von β-Zellen |
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| Sprache: |
Deutsch |
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| Beteiligte Personen: |
Sahr, Anika [VerfasserIn] |
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| Hochschulschrift: |
Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2019 |
| Links: |
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| BKL: | |
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| Themen: |
B-Zelle |
| Anmerkungen: |
Literaturverzeichnis: Seite 153-185 |
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| Umfang: |
1 Online-Ressource (PDF-Datei: 196 Seiten, 7775 Kilobyte) ; Illustrationen (teilweise farbig), Diagramme (teilweise farbig) |
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| Weitere IDs: |
urn:nbn:de:gbv:9-opus-29237 |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Untersuchungen zum Einfluss des Mas-Rezeptors auf die Funktion von β-Zellen |c vorgelegt von Anika Sahr ; 1. Gutachter: Prof. Dr. Reinhard Walther, 2. Gutachter: PD Dr. Matthias Elsner |
| 264 | 1 | |a Greifswald |c September 2018 | |
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| 520 | |a B-Zelle, Diabetes mellitus, Insulin, Insulinsekretion, Langerhans-Inseln, Renin-Angiotensin-System, Mas-Rezeptor | ||
| 520 | |a The renin-angiotensin system (RAS) is a hormonal system that can influence diverse physiological processes by binding of angiotensin peptides to their specific receptors. In recent years, the alternative angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor axis of the RAS has come into focus of research due to its protective role in pathophysiological states. The relevance of the local ACE2/Ang-(1-7)/Mas axis for the function of islets of Langerhans, especially with regard to the production and secretion of insulin, has been little investigated so far. Therefore, the aim of the present work was to determine the influence of the Mas receptor and its ligand Ang-(1-7) on β-cell function and to elucidate responsible molecular mechanisms. For this purpose, isolated islets from of wild-type (WT) and Mas-deficient mice were used, which were initially characterised comprehensively with regard to the expression of components of the ACE2/Ang-(1-7)/Mas axis. The influence of Ang-(1-7) and Ang-(1-7) antagonists D-Ala7-Ang-(1-7) (A779) and D-Pro7-Ang-(1-7) (D-Pro) on insulin production and glucose-stimulated insulin secretion (GSIS) was then determined. Isolated islets of Mas-deficient mice showed a significantly reduced GSIS compared to WT islets. Accordingly, incubation of WT islets with A779 and D-Pro resulted in a reduced GSIS, whereas the Mas-ligand Ang-(1-7) was able to significantly increase GSIS. These findings underline the relevance of the ACE2/Ang-(1-7) ... | ||
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