Details der Publikation - Outcome of renal transplantation in small infants

Outcome of renal transplantation in small infants : a match-controlled analysis / Marcus Weitz, Guido F. Laube, Maria Schmidt, Kai Krupka, Luisa Murer, Dominik Müller, Bernd Hoppe, Anja Büscher, Jens König, Martin Pohl, Therese Jungraithmayr, Florian Thiel, Heiko Billing, Ryszard Grenda, Jacek Rubik, Michael M. Kaabak, Fatos Yalcinkaya, Rezan Topaloglu, Nicholas Webb, Luca Dello Strologo, Lars Pape, Silvio Nadalin, Burkhard Tönshoff

BACKGROUND: Infants with a body weight of less than 10 kg are often not considered to be suitable candidates for renal transplantation (RTx). The objective of this study was to evaluate this arbitrary weight threshold for pediatric RTx. - METHODS: We conducted a multicenter, retrospective, match-controlled cohort study on infants weighing less than 10 kg at time of engrafting (low-weight group [LWG], n = 38) compared to a matched control group (n = 76) with a body weight of 10-15 kg, using data from the first 2 years post-transplant derived from the CERTAIN Registry. - RESULTS: Patient survival was 97 and 100% in the LWG and control groups, respectively (P = 0.33), and death-censored graft survival was 100 and 95% in the LWG and control groups, respectively (P = 0.30). Estimated glomerular filtration rate at 2 years post-transplant was excellent and comparable between the groups (LWG 77.6 ± 34.9 mL/min/1.73 m2; control 74.8 ± 29.1 mL/min/1.73 m2; P = 0.68). The overall incidences of surgery-related complications (LWG 11%, control 23%; P = 0.12) and medical outcome measures (LWG 23%, control 36%, P = 0.17) were not significantly different between the groups. The medical outcome measures included transplant-related viral diseases (LWG 10%, control 21%; P = 0.20), acute rejection episodes (LWG 14%, control 29%; P = 0.092), malignancies (LWG 3%, control 0%; P = 0.33) and arterial hypertension (LWG 73%, control 67%; P = 0.57). - CONCLUSIONS: These data suggest that RTx in low-weight children is a feasible option, at least in selected centers with appropriate surgical and medical expertise..

Medienart:	E-Artikel

Erscheinungsjahr:	13 March 2018 2018
Erschienen:	13 March 2018

Enthalten in:	Zur Gesamtaufnahme - volume:33
Enthalten in:	Pediatric nephrology - 33(2018), 6, Seite 1057-1068

Sprache:	Englisch

Beteiligte Personen:	Weitz, Marcus, 1974- [VerfasserIn] Krupka, Kai [VerfasserIn] Tönshoff, Burkhard [VerfasserIn]

Links:	Volltext

Themen:	Body Weight Case-Control Studies Child, Preschool Children Cohort Studies Female Graft Survival Humans Infant Infants Kidney Failure, Chronic Kidney Transplantation Male Medical complications Postoperative Complications Registries Renal transplantation Retrospective Studies Risk Factors Surgical complications Thinness Treatment Outcome

Anmerkungen:	Gesehen am 04.07.2019

Umfang:	12

doi:	10.1007/s00467-018-3895-5

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1668621703

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520			\|a BACKGROUND: Infants with a body weight of less than 10 kg are often not considered to be suitable candidates for renal transplantation (RTx). The objective of this study was to evaluate this arbitrary weight threshold for pediatric RTx. - METHODS: We conducted a multicenter, retrospective, match-controlled cohort study on infants weighing less than 10 kg at time of engrafting (low-weight group [LWG], n = 38) compared to a matched control group (n = 76) with a body weight of 10-15 kg, using data from the first 2 years post-transplant derived from the CERTAIN Registry. - RESULTS: Patient survival was 97 and 100% in the LWG and control groups, respectively (P = 0.33), and death-censored graft survival was 100 and 95% in the LWG and control groups, respectively (P = 0.30). Estimated glomerular filtration rate at 2 years post-transplant was excellent and comparable between the groups (LWG 77.6 ± 34.9 mL/min/1.73 m2; control 74.8 ± 29.1 mL/min/1.73 m2; P = 0.68). The overall incidences of surgery-related complications (LWG 11%, control 23%; P = 0.12) and medical outcome measures (LWG 23%, control 36%, P = 0.17) were not significantly different between the groups. The medical outcome measures included transplant-related viral diseases (LWG 10%, control 21%; P = 0.20), acute rejection episodes (LWG 14%, control 29%; P = 0.092), malignancies (LWG 3%, control 0%; P = 0.33) and arterial hypertension (LWG 73%, control 67%; P = 0.57). - CONCLUSIONS: These data suggest that RTx in low-weight children is a feasible option, at least in selected centers with appropriate surgical and medical expertise.
650		4	\|a Body Weight
650		4	\|a Case-Control Studies
650		4	\|a Child, Preschool
650		4	\|a Children
650		4	\|a Cohort Studies
650		4	\|a Female
650		4	\|a Graft Survival
650		4	\|a Humans
650		4	\|a Infant
650		4	\|a Infants
650		4	\|a Kidney Failure, Chronic
650		4	\|a Kidney Transplantation
650		4	\|a Male
650		4	\|a Medical complications
650		4	\|a Postoperative Complications
650		4	\|a Registries
650		4	\|a Renal transplantation
650		4	\|a Retrospective Studies
650		4	\|a Risk Factors
650		4	\|a Surgical complications
650		4	\|a Thinness
650		4	\|a Treatment Outcome
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