A specialist periodical report : Amino acids, peptides and proteins / editors: Maxim Ryadnov (National Physical Laboratory, UK), Ferenc Hudecz (Eötvös Lorand University, Hungary)

Cover; Preface; Contents; A short guide to abbreviations and their use in peptide science; Search and destroy: versatile proteins offer unique structural solutions against uracil in DNA; 1 The widening chemical space of DNA; 2 Uracil in DNA: occurrence and metabolism; 2.1 Occurrence; 2.2 Repair; 3 Structural solutions for uracil recognition in diverse enzyme families; 3.1 Incorporation of uracil into the dUTPase active site; 3.2 Recognition of uracil in different families of uracil-DNA glycosylases; 4 Potential physiological roles for uracil in DNA; List of abbreviations; Acknowledgments.

List of abbreviationsReferences; Branched polymeric polypeptides with poly[Lys]; 1 Introduction; 2 Synthesis; 2.1 Synthesis and characterization of poly[Lys]; 2.2 Synthesis of poly[Lys(Xi-DL-Alam)] (XAK), i<1, m~3 polymeric polypeptides; 2.3 Synthesis of poly[Lys(DL-Serm-X)] (XSK), m~3 polymeric polypeptides; 2.4 Synthesis of poly[Lys(DL-Alam-Xi)] (AXK), i<1, m~3 polymeric polypeptides; 2.4.1 Poly[Lys(Xi)], (XiK) polypeptides, i<1; 2.4.2 Poly[Lys(DL-Alam-Xi)] (AXK) polypeptides i<1, m~3; 2.5 Poly[Lys-(X-DL-Ala3)n] (A3XK) and poly[Lys-(DL-Ala3-X)n] (XA3K) polymeric polypeptides.

2.6 Characterization of branched chain polypeptides with poly[Lys] backbone3 Conformation of branched polypeptides in solution; 3.1 The influence of the identity of amino acid X at the N-terminal of the branches; 3.2 The influence of the position of amino acid X in the branches; 4 Chemical structure -- biological properties; 4.1 Interaction with biomembrane models; 4.2 Biodegradation, in vitro cytotoxicity, immunoreactivity; 4.2.1 Cytotoxicity; 4.2.2 Immunoreactivity; 4.3 Biodistribution, cellular uptake; 4.3.1 Biodistribution; 4.3.2 Cellular uptake; 4.3.2.1 Uptake by tumour cells.

4.3.2.2 Uptake by macrophages5 Branched polypeptide bioconjugates; 5.1 Conjugates with reporter entity; 5.2 Conjugates with chemotherapeutic agent; 5.3 Conjugates with epitope oligopeptides or haptens; 5.3.1 Carrier effect on cell membrane stability and penetration; 5.3.2 Peptide conjugates as target antigens; 5.3.3 Peptide conjugates as immunogens; 6 Conclusion, perspectives; Abbreviations; Acknowledgments; References; Peptide-mediated pathogenesis of Alzheimer's disease; 1 Introduction; 2 Structure and function of wild-type tau protein; 2.1 Tau modifications underpinning AD symptoms.

Medienart:	E-Book

Erscheinungsjahr:	2019 © 2019
Erschienen:	Cambridge: Royal Society of Chemistry ; 2019 © 2019

Reihe:	Amino acids, peptides and proteins - 43 Specialist periodical reports - 43

Sprache:	Englisch

Beteiligte Personen:	Ryadnov, Maxim [HerausgeberIn] Hudecz, Ferenc [HerausgeberIn]

Links:	Volltext [lizenzpflichtig]

ISBN:	978-1-78801-385-7 1-78801-385-9 978-1-78801-866-1

Themen:	Amino acids Peptides Proteins SCIENCE ; Life Sciences ; Biochemistry

Umfang:	1 Online-Ressource (154 Seiten)

doi:	10.1039/9781788013857

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1668128330