IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidney / Lehel Peterfi, Maria V. Yusenko, Gyula Kovacs
BACKGROUND/AIM: Chronic inflammation in end-stage kidney is associated with the development of pre-neoplastic lesions and renal cell tumors. The aim of this study was to clarify the role of the inflammatory microenvironment in this process. - MATERIALS AND METHODS: We used representative microscopic slides from 11 end stage-kidneys containing pre-neoplastic lesions and tumors and applied immunohistochemistry to detect IL-6, SAA1 and LBP expression. We also applied array-based comparative genomic hybridization (CGH) analysis to detect genomic changes in tumor cells. - RESULTS: We identified strong expression of IL6, LBP and SAA1 in activated stromal fibroblasts, in proliferating epithelial and tumor cells. Array CGH detected unusual genomic changes in tumor cells. - CONCLUSION: Our data indicate that expression of IL6, acute phase protein SAA1 and LBP maintain a long-lasting inflammatory microenvironment that leads to remodeling of end-stage kidneys and the development of unique types of renal cell tumors..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2019 |
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Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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Enthalten in: |
Anticancer research - 39(2019), 4, Seite 1869-1874 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Peterfi, Lehel [VerfasserIn] |
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Links: |
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Anmerkungen: |
Gesehen am 06.06.2019 |
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Umfang: |
6 |
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doi: |
10.21873/anticanres.13294 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
1666940267 |
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