Details der Publikation - Fertility preservation

Fertility preservation : ovarian response to freeze oocytes is not affected by different malignant diseases-an analysis of 992 stimulations / M. von Wolff, T. Bruckner, T. Strowitzki, A. Germeyer

PURPOSE: To study if ovarian response is affected by the type of disease if fertility preservation is required. - METHODS: A registry of the trinational fertility preservation network FertiPROTEKT including 992 patients aged 18-40 years undergoing ovarian stimulation and follicle aspiration for fertility preservation from 1/2007 until 3/2016 was analysed. The number of collected oocytes, days of stimulation, total gonadotropin dosage and gonadotropin dosage per day were evaluated. - RESULTS: Total oocyte number was negatively correlated with increasing age (r = 0.237, p < 0.0001). Oocyte numbers were in women < 26 years 15.4 ± 8.8, 26-30 years 13.1 ± 8.5, 31-35 years 12.2 ± 7.7 and 36-40 years 9.9 ± 8.0. Age-adjusted oocyte numbers were not different in women with Hodgkin's lymphoma (12.6 ± 8.8), non-Hodgkin's lymphoma (12.4 ± 8.2), leukaemia (11.7 ± 8.2), sarcoma (11.8 ± 8.2), cerebral cancer (16.5 ± 8.1), gastrointestinal cancer (13.2 ± 8.1) gynaecological cancer (10.8 ± 8.2) and other types of malignancies (15.8 ± 8.1) apart from ovarian cancer with lower oocyte yield (7.3 ± 8.3, p < 0.001) compared to women with breast cancer (13.3 ± 8.8). The total gonadotropin dose used for stimulation was only elevated in Hodgkin's and non-Hodgkin's lymphoma compared to women with breast cancer (p < 0.05). Oocyte yield was lower in women with versus without ovarian cancer (p < 0.0001). - CONCLUSIONS: As ovarian response is not affected by the type of cancer, ovarian stimulation can be performed with the same oocyte yield in different malignant diseases. However, oocyte yield is reduced if ovarian surgery is required and in older women..

Medienart:	E-Artikel

Erscheinungsjahr:	05 June 2018 2018
Erschienen:	05 June 2018

Enthalten in:	Zur Gesamtaufnahme - volume:35
Enthalten in:	Journal of assisted reproduction and genetics - 35(2018), 9, Seite 1713-1719

Sprache:	Englisch

Beteiligte Personen:	Wolff, Michael von, 1966- [VerfasserIn] Bruckner, Thomas, 1956- [VerfasserIn] Strowitzki, Thomas, 1959- [VerfasserIn] Germeyer, Ariane, 1973- [VerfasserIn]

Links:	Volltext

Themen:	Adolescent Adult Breast Neoplasms Breast cancer Cryopreservation Female Fertility Preservation Fertility preservation Hodgkin’s lymphoma Hodgkin Disease Humans Oocyte Oocyte Retrieval Oocytes Ovarian Neoplasms Ovarian cancer Ovarian stimulation Ovary Ovulation Induction Pregnancy Young Adult

Anmerkungen:	Gesehen am 09.04.2019

Umfang:	7

doi:	10.1007/s10815-018-1227-0

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1662999356

Internformat


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650		4	\|a Adolescent
650		4	\|a Adult
650		4	\|a Breast cancer
650		4	\|a Breast Neoplasms
650		4	\|a Cryopreservation
650		4	\|a Female
650		4	\|a Fertility preservation
650		4	\|a Fertility Preservation
650		4	\|a Hodgkin Disease
650		4	\|a Hodgkin’s lymphoma
650		4	\|a Humans
650		4	\|a Oocyte
650		4	\|a Oocyte Retrieval
650		4	\|a Oocytes
650		4	\|a Ovarian cancer
650		4	\|a Ovarian Neoplasms
650		4	\|a Ovarian stimulation
650		4	\|a Ovary
650		4	\|a Ovulation Induction
650		4	\|a Pregnancy
650		4	\|a Young Adult
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Fertility preservation : ovarian response to freeze oocytes is not affected by different malignant diseases-an analysis of 992 stimulations / M. von Wolff, T. Bruckner, T. Strowitzki, A. Germeyer

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