Heme Biology : The Secret Life of Heme in Regulating Diverse Biological Processes

Key Features:There are no other books published to-date that focus on the biology of heme, and the roles of heme in regulating diverse biological processesThe editor is a recognized expert in the regulatory functions of heme and has published many peer-reviewed papers on the subject..

Intro -- CONTENTS -- Preface -- List of Contributors -- Chapter 1 Introduction Li Zhang -- Overview -- References -- Chapter 2 Heme Biosynthesis and Degradation: What Happens when it goes Haywire? Li Zhang and Rebekah Sessoms -- Overview -- Heme is synthesized by the actions of eight enzymes in humans -- Heme biosynthesis is regulated according to the needs for heme in human cells -- Defective heme biosynthesis causes serious diseases in humans -- Heme is degraded continuously in the human body -- Defects in heme degradation can cause serious diseases -- References -- Chapter 3 Heme: An Ingenious Regulator of Gene Transcription Li Zhang -- Overview -- Heme can control the activity of diverse transcriptional regulators -- Heme serves as a secondary messenger of oxygen in yeast -- Heme can control the expression of a high number of genes in yeast -- The heme activator protein Hap1 is a key regulator of gene transcription in response to fluctuations in oxygen and heme levels -- Heme regulation of Hap1 transcription-activating activity requires the proper functioning of Hsp90 and Hsp70 molecular chaperones -- Bach1: A heme-dependent transcriptional regulator in mammalian cells -- Bach1, like Hap1, binds to heme via HRMs -- Heme affects Bach1 at three levels -- Perspectives -- References -- Chapter 4 Heme-Regulated eIF2α Kinase in Translation and Erythropoiesis Jane-Jane Chen and Rajasekhar NVS Suragani -- Overview -- Introduction -- HRI is responsible for heme-regulated translation in erythroid precursors -- Phosphorylation of eIF2α under diverse cellular stresses by the family of eIF2α kinases -- Activation of HRI by autophosphorylation -- Inhibition of HRI activity by heme -- Two distinct heme-binding domains in the cooperation of heme-regulation of HRI -- Tissue expression and phylogenetic conservation of HRI..

Medienart:	E-Book

Erscheinungsjahr:	2014 ©2011.
Erschienen:	Singapore: World Scientific Publishing Co Pte Ltd ; 2014 ©2011.

Sprache:	Englisch

Beteiligte Personen:	Zhang, Li [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

ISBN:	978-981-4287-93-7

Themen:	Electronic books Heme

Anmerkungen:	Description based on publisher supplied metadata and other sources

Umfang:	1 online resource (226 pages)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	1658008944