Cancer stem cells : novel concepts and prospects for tumor therapy / O. D. Wiestler, B. Haendler, D. Mumberg, eds.

Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells. This book looks at recent developments in the field of cancer stem cells and the possible impact for the identification of novel treatment paradigms for cancer..

Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells, thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell proliferation and survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against cancer stem cells offers great therapeutic opportunities but also provides for major challenges regarding preclinical models, therapeutic windows, and clinical study end points..

Medienart:

E-Book

Erscheinungsjahr:

2007

Erschienen:

Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg ; 2007

Weitere Ausgaben:

Druckausg.: Cancer stem cells

Reihe:

Springer Series on Biofilms - 2006/5

Ernst Schering Foundation Symposium Proceedings - 2006/5

SpringerLink, Bücher

Sprache:

Englisch

Beteiligte Personen:

Wiestler, Otmar D., 1956- [HerausgeberIn]
Haendler, B. [HerausgeberIn]
Mumberg, D. [HerausgeberIn]

Congresses:

Cancer Stem Cell Workshop ; Berlin ; 2006.11.15-17

Links:

Volltext
Volltext [lizenzpflichtig]
Cover
Inhaltsverzeichnis

ISBN:

978-3-540-70853-7

Nlm:

QZ 202

W1

BKL:

44.81 / Onkologie

Themen:

Antineoplastic Agents
Aufsatzsammlung
Biomedicine
Cancer research
Human genetics
Konferenzschrift
Krebs
Medicine
Neoplasms
Neoplastic Stem Cells
Oncology
Signal Transduction
Stammzelle

RVK:

RVK Klassifikation

Anmerkungen:

Includes bibliographical references

Umfang:

Online-Ressource (XVI, 263 p, online resource)

doi:

10.1007/978-3-540-70853-7

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

1647124166