Selective attenuation of electrophysiological activity of the dentate gyrus in a social defeat mouse model / Yuki Aoki, Yuya Nishimura, Timm Hondrich, Ryota Nakayama, Hideyoshi Igata, Takuya Sasaki, Yuji Ikegaya
Current research on stress pathology has revealed a set of molecular and cellular mechanisms through which psychosocial stress impairs brain function. However, there are few studies that have examined how chronic stress exposure alters neuronal activity patterns at a network level. Here, we recorded ensemble neuronal activity patterns of the cortico-hippocampal network from urethane-anesthetized mice that were subjected to repeated social defeat stress. In socially defeated mice, the magnitudes of local field potential signals, including theta, slow gamma, and fast gamma oscillations, were significantly reduced in the dentate gyrus, whereas they remained unchanged in the hippocampus and somatosensory cortex. In accordance with the vast majority of histological and biochemical studies, our evidence from electrophysiological investigations highlights the dentate gyrus as a key brain area that is primarily susceptible to stress-induced dysfunction..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
|---|---|
| Enthalten in: |
The journal of physiological sciences - 67(2017), 4, Seite 507-513 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Aoki, Yuki [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Published online: 29 August 2016 Gesehen am 26.06.2018 |
|---|
| Umfang: |
7 |
|---|
| doi: |
10.1007/s12576-016-0481-0 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
1576847004 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | 1576847004 | ||
| 003 | DE-627 | ||
| 005 | 20220814174324.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180626r20172016xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12576-016-0481-0 |2 doi | |
| 035 | |a (DE-627)1576847004 | ||
| 035 | |a (DE-576)506847004 | ||
| 035 | |a (DE-599)BSZ506847004 | ||
| 035 | |a (OCoLC)1341012646 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 100 | 1 | |a Aoki, Yuki |e verfasserin |0 (DE-588)1161754318 |0 (DE-627)1025205510 |0 (DE-576)506848221 |4 aut | |
| 245 | 1 | 0 | |a Selective attenuation of electrophysiological activity of the dentate gyrus in a social defeat mouse model |c Yuki Aoki, Yuya Nishimura, Timm Hondrich, Ryota Nakayama, Hideyoshi Igata, Takuya Sasaki, Yuji Ikegaya |
| 264 | 1 | |c 2017 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 29 August 2016 | ||
| 500 | |a Gesehen am 26.06.2018 | ||
| 520 | |a Current research on stress pathology has revealed a set of molecular and cellular mechanisms through which psychosocial stress impairs brain function. However, there are few studies that have examined how chronic stress exposure alters neuronal activity patterns at a network level. Here, we recorded ensemble neuronal activity patterns of the cortico-hippocampal network from urethane-anesthetized mice that were subjected to repeated social defeat stress. In socially defeated mice, the magnitudes of local field potential signals, including theta, slow gamma, and fast gamma oscillations, were significantly reduced in the dentate gyrus, whereas they remained unchanged in the hippocampus and somatosensory cortex. In accordance with the vast majority of histological and biochemical studies, our evidence from electrophysiological investigations highlights the dentate gyrus as a key brain area that is primarily susceptible to stress-induced dysfunction. | ||
| 534 | |c 2016 | ||
| 650 | 4 | |a Aggression | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Behavior, Animal | |
| 650 | 4 | |a Brain Waves | |
| 650 | 4 | |a Dentate gyrus | |
| 650 | 4 | |a Dentate Gyrus | |
| 650 | 4 | |a Disease Models, Animal | |
| 650 | 4 | |a Hippocampus | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Mice, Inbred C57BL | |
| 650 | 4 | |a Nerve Net | |
| 650 | 4 | |a Network | |
| 650 | 4 | |a Social Behavior | |
| 650 | 4 | |a Social stress | |
| 650 | 4 | |a Somatosensory Cortex | |
| 650 | 4 | |a Stress, Psychological | |
| 650 | 4 | |a Time Factors | |
| 700 | 1 | |a Hondrich, Timm |e verfasserin |0 (DE-588)1161755691 |0 (DE-627)1025208331 |0 (DE-576)506851516 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of physiological sciences |d [Tokyo] : Springer, 2006 |g 67(2017), 4, Seite 507-513 |w (DE-627)572081235 |w (DE-600)2437104-X |w (DE-576)30683698X |x 1880-6562 |7 nnns |
| 773 | 1 | 8 | |g volume:67 |g year:2017 |g number:4 |g pages:507-513 |g extent:7 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s12576-016-0481-0 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ILN_2013 | ||
| 912 | |a ISIL_DE-16-250 | ||
| 912 | |a SYSFLAG_1 | ||
| 912 | |a GBV_KXP | ||
| 912 | |a GBV_ILN_20 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_23 | ||
| 912 | |a GBV_ILN_24 | ||
| 912 | |a GBV_ILN_31 | ||
| 912 | |a GBV_ILN_39 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_60 | ||
| 912 | |a GBV_ILN_62 | ||
| 912 | |a GBV_ILN_63 | ||
| 912 | |a GBV_ILN_65 | ||
| 912 | |a GBV_ILN_69 | ||
| 912 | |a GBV_ILN_73 | ||
| 912 | |a GBV_ILN_74 | ||
| 912 | |a GBV_ILN_90 | ||
| 912 | |a GBV_ILN_95 | ||
| 912 | |a GBV_ILN_100 | ||
| 912 | |a GBV_ILN_101 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_110 | ||
| 912 | |a GBV_ILN_120 | ||
| 912 | |a GBV_ILN_151 | ||
| 912 | |a GBV_ILN_152 | ||
| 912 | |a GBV_ILN_161 | ||
| 912 | |a GBV_ILN_170 | ||
| 912 | |a GBV_ILN_187 | ||
| 912 | |a GBV_ILN_206 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_250 | ||
| 912 | |a GBV_ILN_281 | ||
| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_293 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_702 | ||
| 912 | |a GBV_ILN_2001 | ||
| 912 | |a GBV_ILN_2003 | ||
| 912 | |a GBV_ILN_2007 | ||
| 912 | |a GBV_ILN_2009 | ||
| 912 | |a GBV_ILN_2011 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_2015 | ||
| 912 | |a GBV_ILN_2021 | ||
| 912 | |a GBV_ILN_2025 | ||
| 912 | |a GBV_ILN_2026 | ||
| 912 | |a GBV_ILN_2031 | ||
| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2037 | ||
| 912 | |a GBV_ILN_2038 | ||
| 912 | |a GBV_ILN_2039 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2108 | ||
| 912 | |a GBV_ILN_2111 | ||
| 912 | |a GBV_ILN_2112 | ||
| 912 | |a GBV_ILN_2113 | ||
| 912 | |a GBV_ILN_2116 | ||
| 912 | |a GBV_ILN_2118 | ||
| 912 | |a GBV_ILN_2119 | ||
| 912 | |a GBV_ILN_2122 | ||
| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
| 912 | |a GBV_ILN_2144 | ||
| 912 | |a GBV_ILN_2147 | ||
| 912 | |a GBV_ILN_2148 | ||
| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2188 | ||
| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2232 | ||
| 912 | |a GBV_ILN_2446 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4035 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4242 | ||
| 912 | |a GBV_ILN_4246 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4367 | ||
| 912 | |a GBV_ILN_4700 | ||
| 912 | |a GBV_ILN_2403 | ||
| 912 | |a GBV_ILN_2403 | ||
| 912 | |a ISIL_DE-LFER | ||
| 936 | u | w | |d 67 |j 2017 |e 4 |h 507-513 |g 7 |
| 951 | |a AR | ||
| 952 | |d 67 |j 2017 |e 4 |h 507-513 |g 7 | ||
| 980 | |2 2013 |1 01 |x DE-16-250 |b 3013805366 |c 00 |f --%%-- |d --%%-- |e --%%-- |j --%%-- |y l01 |z 26-06-18 | ||
| 980 | |2 2403 |1 01 |x DE-LFER |b 3017149269 |c 00 |f --%%-- |d --%%-- |e n |j --%%-- |y l01 |z 10-07-18 | ||
| 981 | |2 2403 |1 01 |x DE-LFER |r http://dx.doi.org/10.1007/s12576-016-0481-0 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 00 |s s |a hd2017 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 01 |s s |0 (DE-627)1410508463 |a wissenschaftlicher Artikel (Zeitschrift) | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 02 |s s |a per_7 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 03 |s s |a s_7 | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s p |0 (DE-627)1576852377 |a Hondrich, Timm | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s k |0 (DE-627)1416733507 |a Interdisziplinäres Zentrum für Neurowissenschaften (IZN) | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s s |0 (DE-627)1410501914 |a Verfasser | ||
| 982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s s |a pos_3 | ||