Potential protective effects of cannabidiol on neuroanatomical alterations in cannabis users and psychosis : a critical review / Derik Hermann and Miriam Schneider
Cannabis use and the development of schizophrenic psychoses share a variety of similarities. Both start during late adolescence; go along with neuropsychological deficits, reduced activity, motivation deficits, and hallucinations suggesting impairment of similar brain structures. In cannabis heavy users diminished regional gray and white matter volume was reported. Similar alterations were observed in the large literature addressing structural abnormalities in schizophrenia. Furthermore, in cannabis using schizophrenic patients, these brain alterations were especially pronounced. Close relatives of schizophrenic patients showed greater cannabis-associated brain tissue loss than non-relatives indicating a genetically mediated particular sensitivity to brain tissue loss. Possible mechanisms for the induction of structural brain alterations are here discussed including impairments of neurogenesis, disturbance of endocannabinoids and diminished neuroplasticity. Especially direct THC effects (or via endocannabinoids) may mediate diminished glutamatergic neurotransmission usually driving neuroplasticity. Correspondingly, alterations of the kynurenic acid blocking NMDA receptors may contribute to brain structure alterations. However, different cannabis compounds may exert opposite effects on the neuroanatomical changes underlying psychosis. In particular, cannabidiol (CBD) was shown to prevent THC associated hippocampal volume loss in a small pilot study. This finding is further supported by several animal experiments supporting neuroprotective properties of CBD mainly via anti-oxidative effects, CB2 receptors or adenosine receptors. We will discuss here the mechanisms by which CBD may reduce brain volume loss, including antagonism of THC, interactions with endocannabinoids, and mechanisms that specifically underlie antipsychotic properties of CBD..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2012 |
---|---|
Erschienen: |
2012 |
Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
---|---|
Enthalten in: |
Current pharmaceutical design - 18(2012), 32, Seite 4897-4905 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Hermann, Derik, 1972- [VerfasserIn] |
---|
Links: |
Volltext [kostenfrei registrierungspflichtig] |
---|
Themen: |
Brain |
---|
Anmerkungen: |
Gesehen am 17.05.2018 |
---|
Umfang: |
9 |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
1575273950 |
---|
LEADER | 01000caa a2200265 4500 | ||
---|---|---|---|
001 | 1575273950 | ||
003 | DE-627 | ||
005 | 20230427042904.0 | ||
007 | cr uuu---uuuuu | ||
008 | 180517s2012 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)1575273950 | ||
035 | |a (DE-576)505273950 | ||
035 | |a (DE-599)BSZ505273950 | ||
035 | |a (OCoLC)1341009539 | ||
040 | |a DE-627 |b ger |c DE-627 |e rda | ||
041 | |a eng | ||
100 | 1 | |a Hermann, Derik |d 1972- |e verfasserin |0 (DE-588)121855139 |0 (DE-627)705679047 |0 (DE-576)292920490 |4 aut | |
245 | 1 | 0 | |a Potential protective effects of cannabidiol on neuroanatomical alterations in cannabis users and psychosis |b a critical review |c Derik Hermann and Miriam Schneider |
264 | 1 | |c 2012 | |
300 | |a 9 | ||
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Gesehen am 17.05.2018 | ||
520 | |a Cannabis use and the development of schizophrenic psychoses share a variety of similarities. Both start during late adolescence; go along with neuropsychological deficits, reduced activity, motivation deficits, and hallucinations suggesting impairment of similar brain structures. In cannabis heavy users diminished regional gray and white matter volume was reported. Similar alterations were observed in the large literature addressing structural abnormalities in schizophrenia. Furthermore, in cannabis using schizophrenic patients, these brain alterations were especially pronounced. Close relatives of schizophrenic patients showed greater cannabis-associated brain tissue loss than non-relatives indicating a genetically mediated particular sensitivity to brain tissue loss. Possible mechanisms for the induction of structural brain alterations are here discussed including impairments of neurogenesis, disturbance of endocannabinoids and diminished neuroplasticity. Especially direct THC effects (or via endocannabinoids) may mediate diminished glutamatergic neurotransmission usually driving neuroplasticity. Correspondingly, alterations of the kynurenic acid blocking NMDA receptors may contribute to brain structure alterations. However, different cannabis compounds may exert opposite effects on the neuroanatomical changes underlying psychosis. In particular, cannabidiol (CBD) was shown to prevent THC associated hippocampal volume loss in a small pilot study. This finding is further supported by several animal experiments supporting neuroprotective properties of CBD mainly via anti-oxidative effects, CB2 receptors or adenosine receptors. We will discuss here the mechanisms by which CBD may reduce brain volume loss, including antagonism of THC, interactions with endocannabinoids, and mechanisms that specifically underlie antipsychotic properties of CBD. | ||
650 | 4 | |a Brain | |
650 | 4 | |a Cannabidiol | |
650 | 4 | |a Humans | |
650 | 4 | |a Marijuana Abuse | |
650 | 4 | |a Neuroprotective Agents | |
650 | 4 | |a Psychoses, Substance-Induced | |
700 | 1 | |a Schneider, Miriam |e verfasserin |0 (DE-588)1054411085 |0 (DE-627)791502813 |0 (DE-576)410252506 |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Current pharmaceutical design |d Hilversum : Bentham Science Publ., 2000 |g 18(2012), 32, Seite 4897-4905 |h Online-Ressource |w (DE-627)325051666 |w (DE-600)2034245-7 |w (DE-576)273880217 |x 1873-4286 |7 nnns |
773 | 1 | 8 | |g volume:18 |g year:2012 |g number:32 |g pages:4897-4905 |g extent:9 |
856 | 4 | 0 | |u https://dx.doi.org/10.2174/138161212802884825 |x Verlag |z kostenfrei registrierungspflichtig |3 Volltext |
912 | |a GBV_USEFLAG_U | ||
912 | |a GBV_ILN_2013 | ||
912 | |a ISIL_DE-16-250 | ||
912 | |a SYSFLAG_1 | ||
912 | |a GBV_KXP | ||
912 | |a SSG-OLC-PHA | ||
912 | |a GBV_ILN_20 | ||
912 | |a GBV_ILN_22 | ||
912 | |a GBV_ILN_24 | ||
912 | |a GBV_ILN_31 | ||
912 | |a GBV_ILN_65 | ||
912 | |a GBV_ILN_69 | ||
912 | |a GBV_ILN_1200 | ||
912 | |a GBV_ILN_2001 | ||
912 | |a GBV_ILN_2003 | ||
912 | |a GBV_ILN_2005 | ||
912 | |a GBV_ILN_2010 | ||
912 | |a GBV_ILN_2011 | ||
912 | |a GBV_ILN_4035 | ||
912 | |a GBV_ILN_4112 | ||
912 | |a GBV_ILN_4125 | ||
912 | |a GBV_ILN_4305 | ||
912 | |a GBV_ILN_4306 | ||
936 | u | w | |d 18 |j 2012 |e 32 |h 4897-4905 |g 9 |
951 | |a AR | ||
952 | |d 18 |j 2012 |e 32 |h 4897-4905 |g 9 | ||
980 | |2 2013 |1 01 |x DE-16-250 |b 3009727143 |c 00 |f --%%-- |d --%%-- |e --%%-- |j --%%-- |y l01 |z 17-05-18 | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 00 |s s |a hd2012 | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 01 |s s |0 (DE-627)1410508463 |a wissenschaftlicher Artikel (Zeitschrift) | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 02 |s s |a per_2 | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 03 |s s |a s_9 | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s p |0 (DE-627)1449696724 |a Hermann, Derik | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s k |0 (DE-627)1416467254 |a Medizinische Fakultät Mannheim | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s s |0 (DE-627)1410501914 |a Verfasser | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 04 |s s |a pos_1 | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s p |0 (DE-627)1480252670 |a Schneider, Miriam | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s k |0 (DE-627)1416467254 |a Medizinische Fakultät Mannheim | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s s |0 (DE-627)1410501914 |a Verfasser | ||
982 | |2 2013 |1 01 |x DE-16-250 |8 05 |s s |a pos_2 |