Suchergebnisse - "Shiozawa, Hideyuki"

PubPharm (25)

1

Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver

enthalten in: Drug metabolism and disposition: the biological fate of chemicals | 2023

von Asano, D. | Nakamura, K. | Nishiya, Y. | +9

2

Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies

enthalten in: Drug metabolism and pharmacokinetics | 2022

von Makino, C. | Watanabe, A. | Kato, M. | +5

3

CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate

enthalten in: Drug metabolism and disposition: the biological fate of chemicals | 2022

von Asano, D. | Hamaue, S. | Zahir, H. | +13

4

Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2021

von Asano, D. | Shibayama, T. | Shiozawa, H. | +5

5

Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase

enthalten in: Xenobiotica | 2021

von Asano, D. | Shibayama, T. | Shiozawa, H. | +5

6

Pharmacokinetics of trastuzumab deruxtecan (T-DXd), a novel anti-HER2 antibody-drug conjugate, in HER2-positive tumour-bearing mice

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2020

von Okamoto, H. | Oitate, M. | Hagihara, K. | +4

7

Pharmacokinetics of trastuzumab deruxtecan (T-DXd), a novel anti-HER2 antibody-drug conjugate, in HER2-positive tumour-bearing mice

enthalten in: Xenobiotica | 2020

von Okamoto, H. | Oitate, M. | Hagihara, K. | +4

8

Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2019

von Nagai, Y. | Oitate, M. | Shiozawa, H. | +1

9

In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats : involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2019

von Makino, C. | Watanabe, A. | Deguchi, T. | +8

10

In vivomultiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

enthalten in: Xenobiotica | 2019

von Makino, C. | Watanabe, A. | Deguchi, T. | +8