Suchergebnisse - "Ohnishi, Shuichi"

PubPharm (20)

1

The Novel In Vitro Method to Calculate Tissue-to-Plasma Partition Coefficient in Humans for Predicting Pharmacokinetic Profiles by Physiologically-Based Pharmacokinetic Model With High Predictability

enthalten in: Journal of pharmaceutical sciences | 2020

von Mayumi, K. | Tachibana, M. | Yoshida, M. | +3

2

Successful Prediction of Human Pharmacokinetics After Oral Administration by Optimized Physiologically Based Pharmacokinetics Approach and Permeation Assay Using Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells

enthalten in: Journal of pharmaceutical sciences | 2020

von Mayumi, K. | Akazawa, T. | Kanazu, T. | +2

3

Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2019

von Ohnishi, S. | Fukumura, K. | Kubota, R. | +1

4

Successful Prediction of Human Pharmacokinetics by Improving Calculation Processes of Physiologically Based Pharmacokinetic Approach

enthalten in: Journal of pharmaceutical sciences | 2019

von Mayumi, K. | Ohnishi, S. | Hasegawa, H.

5

Pharmacokinetic-Pharmacodynamic Modeling of Brain Dopamine Levels Based on Dopamine Transporter Occupancy after Administration of Methylphenidate in Rats

enthalten in: The Journal of pharmacology and experimental therapeutics | 2019

von Shimizu, R. | Horiguchi, N. | Yano, K. | +4

6

Minimal contribution of P-gp on the low brain distribution of naldemedine, a peripherally acting μ-opioid receptor antagonist

enthalten in: Drug metabolism and pharmacokinetics | 2019

von Watari, R. | Matsuda, A. | Ohnishi, S. | +1

7

Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects

enthalten in: Xenobiotica | 2019

von Ohnishi, S. | Fukumura, K. | Kubota, R. | +1

8

Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine

enthalten in: Drug metabolism and disposition: the biological fate of chemicals | 2018

von Akazawa, T. | Yoshida, S. | Ohnishi, S. | +3

9

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization

enthalten in: Journal of medicinal chemistry | 2018

von Nakahara, K. | Fuchino, K. | Komano, K. | +20

10

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors : Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

enthalten in: Journal of medicinal chemistry | 2018

von Fuchino, K. | Mitsuoka, Y. | Masui, M. | +22