Systemic cytokines related to cognitive function 6-9 months and 12-15 months after SARS- CoV-2 infection

<title>Abstract</title> Background. Cognitive symptoms persisting beyond the acute phase of COVID-19 infection are commonly described for up to 1 year after infection. The relationship between cognitive performance, in particular episodic memory processes observed chronically after infection, and cytokine levels in the acute phase of COVID-19 has not yet been identified in humans. Aim. Determine whether the levels of cytokines IL1β, IL-6 and TNFα secreted in the acute phase of SARS-CoV-2 infection are associated and predict verbal and visuospatial episodic memory performance in humans 6 to 9 months and 12 to 15 months post-infection. Method. The associations and predictive value of the concentration of cytokines measured in acute phase (IL-1β, IL-6, TNFα) from plasma samples of <italic>N</italic> = 33 hospitalised COVID-19 patients (mean age 61 years, 39–78, 65% in intensive care) in relation to their verbal and visuospatial episodic memory performance measured at 6–9 months and 12–15 months post-infection were analyzed. To do this, we used Spearman correlations and generalised linear mixed models. Results. IL-1β levels were associated with verbal episodic memory total recall scores 6–9 months post-infection. At 12–15 months post-infection IL-1β predicted verbal episodic memory scores and IL-6 predicted visuo-perceptive process. Conclusion. This study demonstrated that the severity of inflammatory reaction at acute phase of SARS-CoV-2 infection predicts verbal episodic memory performance in the long-term post-infection..

Media Type:

Preprint

Year of Publication:

2024

Publication:

2024

Contained In:

ResearchSquare.com - (2024) vom: 07. Okt. To Main Record - year:2024

Language:

English

Contributors:

Nuber-Champier, Anthony [Author]
Breville, Gautier [Author]
Voruz, Philippe [Author]
de Alcântara, Isabele Jacot [Author]
Cionca, Alexandre [Author]
Allali, Gilles [Author]
Lalive, Patrice H [Author]
Benzakour, Lamyae [Author]
Lövblad, Karl-Olof [Author]
Braillard, Olivia [Author]
Nehme, Mayssam [Author]
Coen, Matteo [Author]
Serratrice, Jacques [Author]
Reny, Jean-Luc [Author]
Pugin, Jérôme [Author]
Guessous, Idris [Author]
Landis, Basil N [Author]
Assal, Frédéric [Author]
Péron, Julie Anne [Author]

Links:

Volltext [lizenzpflichtig]
Volltext [kostenfrei]

Keywords:

570
Biology

doi:

10.21203/rs.3.rs-4375482/v1

funding:

Supporting institution / Project title:

PPN (Catalogue-ID):

XRA043667236