Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection
The spread of SARS-CoV-2 across the world requires the formation of a range of interventions that include immunomodulatory or antiviral therapeutics and repurposing of existing drug compounds is an important strategy to rapidly identify possible options. Niclosamide is a cheap and generic drug compound with a proven in vitro ability to inhibit viral replication of SARS-CoV-2; this drug also has known poor oral bioavailability due to very low water solubility. Here, we demonstrate the nanoparticle formulation of niclosamide using a new, cheap and scalable process to enable long-acting injectable administration and show extended circulating drug exposure in vivo over 28 days using a rodent model after depot injection..
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Preprint| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
chemRxiv.org - (2021) vom: 18. Nov. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hobson, James [VerfasserIn] |
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| doi: |
10.26434/chemrxiv.13587035 |
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| 245 | 1 | 0 | |a Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection |
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| 520 | |a The spread of SARS-CoV-2 across the world requires the formation of a range of interventions that include immunomodulatory or antiviral therapeutics and repurposing of existing drug compounds is an important strategy to rapidly identify possible options. Niclosamide is a cheap and generic drug compound with a proven in vitro ability to inhibit viral replication of SARS-CoV-2; this drug also has known poor oral bioavailability due to very low water solubility. Here, we demonstrate the nanoparticle formulation of niclosamide using a new, cheap and scalable process to enable long-acting injectable administration and show extended circulating drug exposure in vivo over 28 days using a rodent model after depot injection. | ||
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| 700 | 1 | |a Dwyer, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Unsworth, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Arshad, Usman |e verfasserin |4 aut | |
| 700 | 1 | |a Pertinez, Henry |e verfasserin |4 aut | |
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| 700 | 1 | |a Tatham, Lee |e verfasserin |4 aut | |
| 700 | 1 | |a Rajoli, Rajith K. R. |e verfasserin |4 aut | |
| 700 | 1 | |a Neary, Megan |e verfasserin |4 aut | |
| 700 | 1 | |a Sharp, Joanne |e verfasserin |4 aut | |
| 700 | 1 | |a Valentijn, Anthony |e verfasserin |4 aut | |
| 700 | 1 | |a David, Christopher |e verfasserin |4 aut | |
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| 700 | 1 | |a Rannard, Steve |e verfasserin |4 aut | |
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