In Silico Docking Analysis Revealed the Potential of Phytochemicals Present in Phyllanthus Amarus and Andrographis Paniculata, Used in Ayurveda Medicine in Inhibiting SARS-CoV-2

No therapeutics and vaccines are available against SARS-CoV-2 at present. In the current study we have made an attempt to provide preliminary evidences for interaction of 35 phytochemicals from two plants (Phyllanthus amarus and Andrographis paniculata used in Ayurveda) with SARS-CoV-2 proteins (S protein, 3CLpro, PLpro and RdRp) through in silico docking analysis. The docking was performed with the aid of AutoDock Vina and ADME and other pharmacokinetic properties were predicted using SWISSADME and admetSAR.

Medienart:

Preprint

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

chemRxiv.org - (2021) vom: 18. Nov. Zur Gesamtaufnahme - year:2021

Sprache:

Englisch

Beteiligte Personen:

Hiremath, Shridhar [VerfasserIn]
H D, Vinay Kumar [VerfasserIn]
M, Nandan [VerfasserIn]
M, Mantesh [VerfasserIn]
S, Shankarappa K [VerfasserIn]
V, Venkataravanappa [VerfasserIn]
C R, Jahir Basha [VerfasserIn]
Reddy, C N Lakshminarayana [VerfasserIn]

Links:

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Themen:

540
Chemistry

doi:

10.26434/chemrxiv.12751361

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

XCH018500439