SARS-CoV-2-specific Humoral and Cell-mediated Immune Responses after Immunization with Inactivated COVID-19 Vaccine in Kidney Transplant Recipients (CVIM 1 Study)

Abstract Immunogenicity following inactivated SARS-CoV-2 vaccination among solid organ transplant recipients has not been assessed. Seventy-five patients (37 kidney transplant [KT] recipients and 38 non-transplant controls) received two doses, at 4-week intervals, of an inactivated whole-virus SARS-CoV-2 vaccine. SARS-CoV-2-specific humoral (HMI) and cell-mediated immunity (CMI) were measured before, 4 weeks post-first dose, and 2 weeks post-second dose. The median age of KT recipients was 50 years (IQR, 42–54) and 89% were receiving calcineurin inhibitors/mycophenolate/corticosteroid regimens. The median time since transplant was 4.5 years (IQR, 2–9.5). Among 35 KT patients, anti-RBD IgG titer after vaccination was not significantly different to baseline, but was significantly lower than in controls (7.8 [95%CI 0.2–15.5] vs 2,691 [95%CI 1,581–3,802], p<0.001) as well as the percentage of surrogate virus neutralizing antibody inhibition (2 [95% CI −1-6] vs 71 [95%CI 61–81], p<0.001). However, the mean of SARS-CoV-2 mixed peptides-specific T-cell responses measured by enzyme-linked immunospot assays was significantly increased compared with baseline (66 [95%CI 36–99] vs. 34 [95%CI 19–50] T-cells/106PBMCs, p=0.02) and comparable to that in controls. Our findings revealed weak HMI and marginal CMI responses in fully vaccinated KT recipients receiving inactivated SARS-CoV-2 vaccine. (Thai Clinical Trials Registry, TCTR20210226002)..

Medienart:

Preprint

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

bioRxiv.org - (2023) vom: 06. Nov. Zur Gesamtaufnahme - year:2023

Sprache:

Englisch

Beteiligte Personen:

Bruminhent, Jackrapong [VerfasserIn]
Sethaudom, Chavachol [VerfasserIn]
Chaumdee, Pongsathon [VerfasserIn]
Boongird, Sarinya [VerfasserIn]
Kiertiburanakul, Sasisopin [VerfasserIn]
Malathum, Kumthorn [VerfasserIn]
Nongnuch, Arkom [VerfasserIn]
Phuphuakrat, Angsana [VerfasserIn]
Jirasiritham, Sopon [VerfasserIn]
Janphram, Chitimaporn [VerfasserIn]
Thotsiri, Sansanee [VerfasserIn]
Upama, Supparat [VerfasserIn]
Assanatham, Montira [VerfasserIn]

Links:

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Themen:

570
Biology

doi:

10.1101/2021.08.02.21261095

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

XBI032328885