Japan COVID-19 Task Force: a nation-wide consortium to elucidate host genetics of COVID-19 pandemic in Japan
Abstract To elucidate the host genetic loci affecting severity of SARS-CoV-2 infection, or Coronavirus disease 2019 (COVID-19), is an emerging issue in the face of the current devastating pandemic. Here, we report a genome-wide association study (GWAS) of COVID-19 in a Japanese population led by the Japan COVID-19 Task Force, as one of the initial discovery GWAS studies performed on a non-European population. Enrolling a total of 2,393 cases and 3,289 controls, we not only replicated previously reported COVID-19 risk variants (e.g., LZTFL1, FOXP4, ABO, and IFNAR2), but also found a variant on 5q35 (rs60200309-A at DOCK2) that was associated with severe COVID-19 in younger (<65 years of age) patients with a genome-wide significant p-value of 1.2 × 10-8 (odds ratio = 2.01, 95% confidence interval = 1.58-2.55). This risk allele was prevalent in East Asians, including Japanese (minor allele frequency [MAF] = 0.097), but rarely found in Europeans. Cross-population Mendelian randomization analysis made a causal inference of a number of complex human traits on COVID-19. In particular, obesity had a significant impact on severe COVID-19. The presence of the population-specific risk allele underscores the need of non-European studies of COVID-19 host genetics..
| Medienart: |
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Preprint| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
bioRxiv.org - (2021) vom: 20. Mai Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Namkoong, Ho [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2021.05.17.21256513 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
XBI020570708 |
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| 520 | |a Abstract To elucidate the host genetic loci affecting severity of SARS-CoV-2 infection, or Coronavirus disease 2019 (COVID-19), is an emerging issue in the face of the current devastating pandemic. Here, we report a genome-wide association study (GWAS) of COVID-19 in a Japanese population led by the Japan COVID-19 Task Force, as one of the initial discovery GWAS studies performed on a non-European population. Enrolling a total of 2,393 cases and 3,289 controls, we not only replicated previously reported COVID-19 risk variants (e.g., LZTFL1, FOXP4, ABO, and IFNAR2), but also found a variant on 5q35 (rs60200309-A at DOCK2) that was associated with severe COVID-19 in younger (<65 years of age) patients with a genome-wide significant p-value of 1.2 × 10-8 (odds ratio = 2.01, 95% confidence interval = 1.58-2.55). This risk allele was prevalent in East Asians, including Japanese (minor allele frequency [MAF] = 0.097), but rarely found in Europeans. Cross-population Mendelian randomization analysis made a causal inference of a number of complex human traits on COVID-19. In particular, obesity had a significant impact on severe COVID-19. The presence of the population-specific risk allele underscores the need of non-European studies of COVID-19 host genetics. | ||
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| 700 | 1 | |a Odani, Toshio |e verfasserin |4 aut | |
| 700 | 1 | |a Amishima, Masaru |e verfasserin |4 aut | |
| 700 | 1 | |a Hattori, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Shichinohe, Yasuo |e verfasserin |4 aut | |
| 700 | 1 | |a Kagaya, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Kita, Toshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ohta, Kazuhide |e verfasserin |4 aut | |
| 700 | 1 | |a Sakagami, Satoru |e verfasserin |4 aut | |
| 700 | 1 | |a Koshida, Kiyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Kentaro |e verfasserin |4 aut | |
| 700 | 1 | |a Shimizu, Tetsuo |e verfasserin |4 aut | |
| 700 | 1 | |a Kozu, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Hiranuma, Hisato |e verfasserin |4 aut | |
| 700 | 1 | |a Gon, Yasuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Izumi, Namiki |e verfasserin |4 aut | |
| 700 | 1 | |a Nagata, Kaoru |e verfasserin |4 aut | |
| 700 | 1 | |a Ueda, Ken |e verfasserin |4 aut | |
| 700 | 1 | |a Taki, Reiko |e verfasserin |4 aut | |
| 700 | 1 | |a Hanada, Satoko |e verfasserin |4 aut | |
| 700 | 1 | |a Kawamura, Kodai |e verfasserin |4 aut | |
| 700 | 1 | |a Ichikado, Kazuya |e verfasserin |4 aut | |
| 700 | 1 | |a Nishiyama, Kenta |e verfasserin |4 aut | |
| 700 | 1 | |a Muranaka, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Kazunori |e verfasserin |4 aut | |
| 700 | 1 | |a Hashimoto, Naozumi |e verfasserin |4 aut | |
| 700 | 1 | |a Wakahara, Keiko |e verfasserin |4 aut | |
| 700 | 1 | |a Koji, Sakamoto |e verfasserin |4 aut | |
| 700 | 1 | |a Omote, Norihito |e verfasserin |4 aut | |
| 700 | 1 | |a Ando, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Kodama, Nobuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kaneyama, Yasunari |e verfasserin |4 aut | |
| 700 | 1 | |a Maeda, Shunsuke |e verfasserin |4 aut | |
| 700 | 1 | |a Kuraki, Takashige |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto, Takemasa |e verfasserin |4 aut | |
| 700 | 1 | |a Yokote, Koutaro |e verfasserin |4 aut | |
| 700 | 1 | |a Nakada, Taka-Aki |e verfasserin |4 aut | |
| 700 | 1 | |a Abe, Ryuzo |e verfasserin |4 aut | |
| 700 | 1 | |a Oshima, Taku |e verfasserin |4 aut | |
| 700 | 1 | |a Shimada, Tadanaga |e verfasserin |4 aut | |
| 700 | 1 | |a Harada, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Ono, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Sakurai, Toshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Shibusawa, Takayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kimizuka, Yoshifumi |e verfasserin |4 aut | |
| 700 | 1 | |a Kawana, Akihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Sano, Tomoya |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, Chie |e verfasserin |4 aut | |
| 700 | 1 | |a Suematsu, Ryohei |e verfasserin |4 aut | |
| 700 | 1 | |a Sageshima, Hisako |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshifuji, Ayumi |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Kazuto |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Saeko |e verfasserin |4 aut | |
| 700 | 1 | |a Ishioka, Kota |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Morio |e verfasserin |4 aut | |
| 700 | 1 | |a Masuda, Makoto |e verfasserin |4 aut | |
| 700 | 1 | |a Wakabayashi, Aya |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, Hiroki |e verfasserin |4 aut | |
| 700 | 1 | |a Ueda, Suguru |e verfasserin |4 aut | |
| 700 | 1 | |a Nishikawa, Masanori |e verfasserin |4 aut | |
| 700 | 1 | |a Chihara, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Takeuchi, Mayumi |e verfasserin |4 aut | |
| 700 | 1 | |a Onoi, Keisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Shinozuka, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Sueyoshi, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Nagasaki, Yoji |e verfasserin |4 aut | |
| 700 | 1 | |a Okamoto, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ishihara, Sayoko |e verfasserin |4 aut | |
| 700 | 1 | |a Shimo, Masatoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Tokunaga, Yoshihisa |e verfasserin |4 aut | |
| 700 | 1 | |a Kusaka, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Ohba, Takehiko |e verfasserin |4 aut | |
| 700 | 1 | |a Isogai, Susumu |e verfasserin |4 aut | |
| 700 | 1 | |a Ogawa, Aki |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Fukuyama, Satoru |e verfasserin |4 aut | |
| 700 | 1 | |a Eriguchi, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yonekawa, Akiko |e verfasserin |4 aut | |
| 700 | 1 | |a Kan-o, Keiko |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto, Koichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kanaoka, Kensuke |e verfasserin |4 aut | |
| 700 | 1 | |a Ihara, Shoichi |e verfasserin |4 aut | |
| 700 | 1 | |a Komuta, Kiyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Yoshiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Chiba, Shigeru |e verfasserin |4 aut | |
| 700 | 1 | |a Yamagata, Kunihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hiramatsu, Yuji |e verfasserin |4 aut | |
| 700 | 1 | |a Kai, Hirayasu |e verfasserin |4 aut | |
| 700 | 1 | |a Asano, Koichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Oguma, Tsuyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Yoko |e verfasserin |4 aut | |
| 700 | 1 | |a Hashimoto, Satoru |e verfasserin |4 aut | |
| 700 | 1 | |a Yamasaki, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Kasamatsu, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Komase, Yuko |e verfasserin |4 aut | |
| 700 | 1 | |a Hida, Naoya |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuburai, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Oyama, Baku |e verfasserin |4 aut | |
| 700 | 1 | |a Takada, Minoru |e verfasserin |4 aut | |
| 700 | 1 | |a Kanda, Hidenori |e verfasserin |4 aut | |
| 700 | 1 | |a Kitagawa, Yuichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Fukuta, Tetsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Miyake, Takahito |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshida, Shozo |e verfasserin |4 aut | |
| 700 | 1 | |a Ogura, Shinji |e verfasserin |4 aut | |
| 700 | 1 | |a Abe, Shinji |e verfasserin |4 aut | |
| 700 | 1 | |a Kono, Yuta |e verfasserin |4 aut | |
| 700 | 1 | |a Togashi, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Takoi, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kikuchi, Ryota |e verfasserin |4 aut | |
| 700 | 1 | |a Ogawa, Shinichi |e verfasserin |4 aut | |
| 700 | 1 | |a Ogata, Tomouki |e verfasserin |4 aut | |
| 700 | 1 | |a Ishihara, Shoichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kanehiro, Arihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Ozaki, Shinji |e verfasserin |4 aut | |
| 700 | 1 | |a Fuchimo, Yasuko |e verfasserin |4 aut | |
| 700 | 1 | |a Wada, Sae |e verfasserin |4 aut | |
| 700 | 1 | |a Fujimoto, Nobukazu |e verfasserin |4 aut | |
| 700 | 1 | |a Nishiyama, Kei |e verfasserin |4 aut | |
| 700 | 1 | |a Terashima, Mariko |e verfasserin |4 aut | |
| 700 | 1 | |a Beppu, Satoru |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshida, Kosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Narumoto, Osamu |e verfasserin |4 aut | |
| 700 | 1 | |a Nagai, Hideaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ooshima, Nobuharu |e verfasserin |4 aut | |
| 700 | 1 | |a Motegi, Mitsuru |e verfasserin |4 aut | |
| 700 | 1 | |a Umeda, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Miyagawa, Kazuya |e verfasserin |4 aut | |
| 700 | 1 | |a Shimada, Hisato |e verfasserin |4 aut | |
| 700 | 1 | |a Endo, Mayu |e verfasserin |4 aut | |
| 700 | 1 | |a Ohira, Yoshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, Masafumi |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Sumito |e verfasserin |4 aut | |
| 700 | 1 | |a Igarashi, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Masamichi |e verfasserin |4 aut | |
| 700 | 1 | |a Sagara, Hironori |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Akihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Ohta, Shin |e verfasserin |4 aut | |
| 700 | 1 | |a Kimura, Tomoyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Shibata, Yoko |e verfasserin |4 aut | |
| 700 | 1 | |a Tanino, Yoshinori |e verfasserin |4 aut | |
| 700 | 1 | |a Nikaido, Takefumi |e verfasserin |4 aut | |
| 700 | 1 | |a Minemura, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, Yuichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hashino, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Shinoki, Masato |e verfasserin |4 aut | |
| 700 | 1 | |a Iwagoe, Hajime |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Fujii, Kazuhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Kishi, Hiroto |e verfasserin |4 aut | |
| 700 | 1 | |a Kanai, Masayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Imamura, Tomonori |e verfasserin |4 aut | |
| 700 | 1 | |a Yamashita, Tatsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Yatomi, Masakiyo |e verfasserin |4 aut | |
| 700 | 1 | |a Maeno, Toshitaka |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Shinichi |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Mai |e verfasserin |4 aut | |
| 700 | 1 | |a Kuramochi, Mizuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kamimaki, Isamu |e verfasserin |4 aut | |
| 700 | 1 | |a Tominaga, Yoshiteru |e verfasserin |4 aut | |
| 700 | 1 | |a Ishii, Tomoo |e verfasserin |4 aut | |
| 700 | 1 | |a Utsugi, Mitsuyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Ono, Akihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Toru |e verfasserin |4 aut | |
| 700 | 1 | |a Kashiwada, Takeru |e verfasserin |4 aut | |
| 700 | 1 | |a Fujita, Kazue |e verfasserin |4 aut | |
| 700 | 1 | |a Saito, Yoshinobu |e verfasserin |4 aut | |
| 700 | 1 | |a Seike, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Omae, Yosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Nannya, Yasuhito |e verfasserin |4 aut | |
| 700 | 1 | |a Ueno, Takafumi |e verfasserin |4 aut | |
| 700 | 1 | |a Takano, Tomomi |e verfasserin |4 aut | |
| 700 | 1 | |a Katayama, Kazuhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Ai, Masumi |e verfasserin |4 aut | |
| 700 | 1 | |a Kumanogoh, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Toshiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hasegawa, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Tokunaga, Katsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Ishii, Makoto |e verfasserin |4 aut | |
| 700 | 1 | |a Koike, Ryuji |e verfasserin |4 aut | |
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| 700 | 1 | |a Okada, Yukinori |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t bioRxiv.org |g (2021) vom: 20. Mai |
| 773 | 1 | 8 | |g year:2021 |g day:20 |g month:05 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1101/2021.05.17.21256513 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XBI | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |j 2021 |b 20 |c 05 | ||
| 953 | |2 045F |a 570 | ||