The Invasive Respiratory Infection Surveillance (IRIS) Initiative reveals significant reductions in invasive bacterial infections during the COVID-19 pandemic

Abstract Background Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis are leading causes of invasive diseases including bacteraemic pneumonia and meningitis, and of secondary infections post-viral respiratory disease. They are typically transmitted via respiratory droplets. We investigated rates of invasive disease due to these pathogens during the early phase of the COVID-19 pandemic.Methods Laboratories in 26 countries across six continents submitted data on cases of invasive disease due to S pneumoniae, H influenzae and N meningitidis from 1 January 2018 to 31 May 2020. Weekly cases in 2020 vs 2018-2019 were compared. Streptococcus agalactiae data were collected from nine laboratories for comparison to a non-respiratory pathogen. The stringency of COVID-19 containment measures was quantified by the Oxford COVID-19 Government Response Tracker. Changes in population movements were assessed by Google COVID-19 Community Mobility Reports. Interrupted time series modelling quantified changes in rates of invasive disease in 2020 relative to when containment measures were imposed.Findings All countries experienced a significant, sustained reduction in invasive diseases due to S pneumoniae, H influenzae and N meningitidis, but not S agalactiae, in early 2020, which coincided with the introduction of COVID-19 containment measures in each country. Similar impacts were observed across most countries despite differing stringency in COVID-19 control policies. There was no evidence of a specific effect due to enforced school closures.Interpretation The introduction of COVID-19 containment policies and public information campaigns likely reduced transmission of these bacterial respiratory pathogens, leading to a significant reduction in life-threatening invasive diseases in many countries worldwide..

Medienart:

Preprint

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

bioRxiv.org - (2020) vom: 23. Nov. Zur Gesamtaufnahme - year:2020

Sprache:

Englisch

Beteiligte Personen:

Brueggemann, Angela B [VerfasserIn]
van Rensburg, Melissa J Jansen [VerfasserIn]
Shaw, David [VerfasserIn]
McCarthy, Noel [VerfasserIn]
Jolley, Keith A [VerfasserIn]
Maiden, Martin CJ [VerfasserIn]
van der Linden, Mark PG [VerfasserIn]
Amin-Chowdhury, Zahin [VerfasserIn]
Bennett, Désirée E [VerfasserIn]
Borrow, Ray [VerfasserIn]
Brandileone, Maria-Cristina C [VerfasserIn]
Broughton, Karen [VerfasserIn]
Campbell, Ruth [VerfasserIn]
Cao, Bin [VerfasserIn]
Casanova, Carlo [VerfasserIn]
Choi, Eun Hwa [VerfasserIn]
Chu, Yiu Wai [VerfasserIn]
Clark, Stephen A [VerfasserIn]
Claus, Heike [VerfasserIn]
Coelho, Juliana [VerfasserIn]
Corcoran, Mary [VerfasserIn]
Cottrell, Simon [VerfasserIn]
Cunney, Robert J [VerfasserIn]
Dalby, Tine [VerfasserIn]
Davies, Heather [VerfasserIn]
de Gouveia, Linda [VerfasserIn]
Deghmane, Ala-Eddine [VerfasserIn]
Demczuk, Walter [VerfasserIn]
Desmet, Stefanie [VerfasserIn]
Drew, Richard J [VerfasserIn]
du Plessis, Mignon [VerfasserIn]
Erlendsdottir, Helga [VerfasserIn]
Fry, Norman K [VerfasserIn]
Fuursted, Kurt [VerfasserIn]
Gray, Steve J [VerfasserIn]
Henriques-Normark, Birgitta [VerfasserIn]
Hale, Thomas [VerfasserIn]
Hilty, Markus [VerfasserIn]
Hoffmann, Steen [VerfasserIn]
Humphreys, Hilary [VerfasserIn]
Ip, Margaret [VerfasserIn]
Jacobsson, Susanne [VerfasserIn]
Johnston, Jillian [VerfasserIn]
Kozakova, Jana [VerfasserIn]
Kristinsson, Karl G [VerfasserIn]
Krizova, Pavla [VerfasserIn]
Kuch, Alicja [VerfasserIn]
Ladhani, Shamez N [VerfasserIn]
Lâm, Thiên-Trí [VerfasserIn]
Lebedova, Vera [VerfasserIn]
Lindholm, Laura [VerfasserIn]
Litt, David [VerfasserIn]
Martin, Irene [VerfasserIn]
Martiny, Delphine [VerfasserIn]
Mattheus, Wesley [VerfasserIn]
McElligott, Martha [VerfasserIn]
Meehan, Mary [VerfasserIn]
Meiring, Susan [VerfasserIn]
Mölling, Paula [VerfasserIn]
Morfeldt, Eva [VerfasserIn]
Morgan, Julie [VerfasserIn]
Mulhall, Robert M [VerfasserIn]
Muñoz-Almagro, Carmen [VerfasserIn]
Murdoch, David R [VerfasserIn]
Murphy, Joy [VerfasserIn]
Musilek, Martin [VerfasserIn]
Mzabi, Alexandre [VerfasserIn]
Perez-Argüello, Amaresh [VerfasserIn]
Perrin, Monique [VerfasserIn]
Perry, Malorie [VerfasserIn]
Redin, Alba [VerfasserIn]
Roberts, Richard [VerfasserIn]
Roberts, Maria [VerfasserIn]
Rokney, Assaf [VerfasserIn]
Ron, Merav [VerfasserIn]
Scott, Kevin [VerfasserIn]
Sheppard, Carmen L. [VerfasserIn]
Siira, Lotta [VerfasserIn]
Skoczyńska, Anna [VerfasserIn]
Sloan, Monica [VerfasserIn]
Slotved, Hans-Christian [VerfasserIn]
Smith, Andrew J [VerfasserIn]
Song, Joon Young [VerfasserIn]
Taha, Muhamed-Kheir [VerfasserIn]
Toropainen, Maija [VerfasserIn]
Tsang, Dominic [VerfasserIn]
Vainio, Anni [VerfasserIn]
van Sorge, Nina M [VerfasserIn]
Varon, Emmanuelle [VerfasserIn]
Vlach, Jiri [VerfasserIn]
Vogel, Ulrich [VerfasserIn]
Vohrnova, Sandra [VerfasserIn]
von Gottberg, Anne [VerfasserIn]
Zanella, Rosemeire C [VerfasserIn]
Zhou, Fei [VerfasserIn]

Links:

Volltext [kostenfrei]

doi:

10.1101/2020.11.18.20225029

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

XBI019382766