Polygenic Risk Scores for Alcohol Involvement Relate to Brain Structure in Substance-Naïve Children: Results from the ABCD Study
ABSTRACT In substance naïve children (n=3,013), polygenic risk score (PRS) for problematic alcohol use was associated with lower volume of the frontal pole and greater cortical thickness of the supramarginal gyrus. Several other areas showed nominal significance. These associations suggest that genetic liability to alcohol involvement may manifest as variability in brain structure prior to consumption of the first alcoholic drink and alter brain morphometry during the start of adolescence..
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Preprint| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
bioRxiv.org - (2021) vom: 15. Dez. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hatoum, Alexander S. [VerfasserIn] |
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| Links: |
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| doi: |
10.1101/2020.07.25.20162032 |
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| PPN (Katalog-ID): |
XBI018453538 |
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| 520 | |a ABSTRACT In substance naïve children (n=3,013), polygenic risk score (PRS) for problematic alcohol use was associated with lower volume of the frontal pole and greater cortical thickness of the supramarginal gyrus. Several other areas showed nominal significance. These associations suggest that genetic liability to alcohol involvement may manifest as variability in brain structure prior to consumption of the first alcoholic drink and alter brain morphometry during the start of adolescence. | ||
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