Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

Abstract A few animals have been suspected to be intermediate hosts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a large-scale single-cell screening of SARS-CoV-2 target cells on a wide variety of animals is missing. Here, we constructed the single-cell atlas for 11 representative species in pets, livestock, poultry, and wildlife. Notably, the proportion of SARS-CoV-2 target cells in cat was found considerably higher than other species we investigated and SARS-CoV-2 target cells were detected in multiple cell types of domestic pig, implying the necessity to carefully evaluate the risk of cats during the current COVID-19 pandemic and keep pigs under surveillance for the possibility of becoming intermediate hosts in future coronavirus outbreak. Furthermore, we screened the expression patterns of receptors for 144 viruses, resulting in a comprehensive atlas of virus target cells. Taken together, our work provides a novel and fundamental strategy to screen virus target cells and susceptible species, based on single-cell transcriptomes we generated for domesticated animals and wildlife, which could function as a valuable resource for controlling current pandemics and serve as an early warning system for coping with future infectious disease threats..

Medienart:

Preprint

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

bioRxiv.org - (2020) vom: 17. Juni Zur Gesamtaufnahme - year:2020

Sprache:

Englisch

Beteiligte Personen:

Chen, Dongsheng [VerfasserIn]
Sun, Jian [VerfasserIn]
Zhu, Jiacheng [VerfasserIn]
Ding, Xiangning [VerfasserIn]
Lan, Tianming [VerfasserIn]
Zhu, Linnan [VerfasserIn]
Xiang, Rong [VerfasserIn]
Ding, Peiwen [VerfasserIn]
Wang, Haoyu [VerfasserIn]
Wang, Xiaoling [VerfasserIn]
Wu, Weiying [VerfasserIn]
Qiu, Jiaying [VerfasserIn]
Wang, Shiyou [VerfasserIn]
Li, Haimeng [VerfasserIn]
An, Fuyu [VerfasserIn]
Bao, Heng [VerfasserIn]
Zhang, Le [VerfasserIn]
Han, Lei [VerfasserIn]
Zhu, Yixin [VerfasserIn]
Wang, Xiran [VerfasserIn]
Wang, Feiyue [VerfasserIn]
Yuan, Yuting [VerfasserIn]
Wu, Wendi [VerfasserIn]
Sun, Chengcheng [VerfasserIn]
Lu, Haorong [VerfasserIn]
Wu, Jihong [VerfasserIn]
Sun, Xinghuai [VerfasserIn]
Zhang, Shenghai [VerfasserIn]
Sahu, Sunil Kumar [VerfasserIn]
Chen, Haixia [VerfasserIn]
Fang, Dongming [VerfasserIn]
Luo, Lihua [VerfasserIn]
Zeng, Yuying [VerfasserIn]
Wu, Yiquan [VerfasserIn]
Cui, ZeHua [VerfasserIn]
He, Qian [VerfasserIn]
Jiang, Sanjie [VerfasserIn]
Ma, Xiaoyan [VerfasserIn]
Feng, Weimin [VerfasserIn]
Xu, Yan [VerfasserIn]
Li, Fang [VerfasserIn]
Liu, Zhongmin [VerfasserIn]
Chen, Lei [VerfasserIn]
Chen, Fang [VerfasserIn]
Jin, Xin [VerfasserIn]
Qiu, Wei [VerfasserIn]
Yang, Huanming [VerfasserIn]
Wang, Jian [VerfasserIn]
Hua, Yan [VerfasserIn]
Liu, Yahong [VerfasserIn]
Liu, Huan [VerfasserIn]
Xu, Xun [VerfasserIn]

Links:

Volltext [kostenfrei]

doi:

10.1101/2020.06.13.149690

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

XBI018157130