Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome
Abstract COVID-19 is associated with lymphopenia and ‘cytokine storm’, but no information is available on specific cellular immune responses to SARS-CoV-2. Here, we characterized SARS-CoV-2-specific CD4+ and CD8+ T-cells in patients with acute respiratory distress syndrome. The spike protein (S) proved a potent T-cell antigen and specific T-cells predominantly produced Th1 cytokines. These novel data are important in vaccine design and will facilitate evaluation of vaccine candidate immunogenicity..
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Preprint| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
bioRxiv.org - (2020) vom: 07. Dez. Zur Gesamtaufnahme - year:2020 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Weiskopf, Daniela [VerfasserIn] |
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| Links: |
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| doi: |
10.1101/2020.04.11.20062349 |
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| funding: |
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| PPN (Katalog-ID): |
XBI017596947 |
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| 520 | |a Abstract COVID-19 is associated with lymphopenia and ‘cytokine storm’, but no information is available on specific cellular immune responses to SARS-CoV-2. Here, we characterized SARS-CoV-2-specific CD4+ and CD8+ T-cells in patients with acute respiratory distress syndrome. The spike protein (S) proved a potent T-cell antigen and specific T-cells predominantly produced Th1 cytokines. These novel data are important in vaccine design and will facilitate evaluation of vaccine candidate immunogenicity. | ||
| 700 | 1 | |a Schmitz, Katharina S. |e verfasserin |4 aut | |
| 700 | 1 | |a Raadsen, Matthijs P. |e verfasserin |4 aut | |
| 700 | 1 | |a Grifoni, Alba |e verfasserin |4 aut | |
| 700 | 1 | |a Okba, Nisreen M.A. |e verfasserin |4 aut | |
| 700 | 1 | |a Endeman, Henrik |e verfasserin |4 aut | |
| 700 | 1 | |a van den Akker, Johannes P.C. |e verfasserin |4 aut | |
| 700 | 1 | |a Molenkamp, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Koopmans, Marion P.G. |e verfasserin |4 aut | |
| 700 | 1 | |a van Gorp, Eric C.M. |e verfasserin |4 aut | |
| 700 | 1 | |a Haagmans, Bart L. |e verfasserin |4 aut | |
| 700 | 1 | |a de Swart, Rik L. |e verfasserin |4 aut | |
| 700 | 1 | |a Sette, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a de Vries, Rory D. |e verfasserin |4 aut | |
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