COVID-19 healthcare demand and mortality in Sweden in response to non-pharmaceutical (NPIs) mitigation and suppression scenarios

Abstract Background While the COVID-19 outbreak in China now appears surpressed, Europe and the US have become the epicenters, both reporting many more deaths than China. Responding to the pandemic, Sweden has taken a different approach aiming to mitigate, not suppressing community transmission, by using physical distancing without lock-downs. Here we contrast consequences of different responses to COVID-19 within Sweden, the resulting demand for care, intensive care, the death tolls, and the associated direct healthcare related costs.Methods We use an age stratified health-care demand extended SEIR compartmental model calibrated to the municipality level for all municipalities in Sweden, and a radiation model describing inter-municipality mobility.Results Our model fit well with the observed deaths in Sweden up to 20th of April, 2020. The intensive care unit (ICU) demand is estimated to reach almost 10,000 patients per day by early May in an unmitigated scenario, far above the pre-pandemic ICU capacity of 526 beds. In contrast, a scenario with moderate physical distancing and shielding of elderly in combination with more effective isolation of infectious individuals would reduce numbers to below 500 per day. This would substantially flatten the curve, extend the epidemic period, but a risk resurgence is expected if measures are relaxed. The different scenarios show quite different death tolls up to the 1th of September, ranging from 5,000 to 41,000 deaths, exluding deaths potentially caused by ICU shortage. Further, analyses of the total all-cause mortality in Stockholm indicate that a confirmed COVID-19 death is associated with a additional 0.40 (95% Cl: 0.24, 0.57) all-cause death.Conclusion The results of this study highlight the impact of different combinations of non-pharmaceutical interventions, especially moderate physical distancing and shielding of elderly in combination with more effective isolation of infectious individuals, on reducing deaths and lower healthcare costs. In less effective mitigation scenarios, the demand on ICU beds would rapidly exceed capacity, showing the tight interconnection between the healthcare demand and physical distancing in the society. These findings have relevance for Swedish policy and response to the COVID-19 pandemic and illustrate the importance of maintaining the level of physical distancing for a longer period to suppress or mitigate the impacts from the pandemic.Key messages <jats:list list-type="bullet">We find physical distancing and isolation of infectious individuals without lockdown is effective in mitigating much of the negative direct health impact from the COVID-19 pandemic in Sweden, but has a higher death toll compared to other Scandinavian countries who did implement a lockdownBetween the start of the Swedish model of physical distancing and shiedling the elderly in March to late April, it appears Sweden has managed to ensure that ICU demands do not exceed ICU capacities and that deaths are substantially reduced compared to a counterfactual scenario.In the counterfactual scenario (eg no public health interventions), the intensive care unit demand is estimated to be almost 20 times higher than the intensive care capacity in Sweden and the number of deaths would be between 40,000 to 60,000Under current mitigation strategies, the death toll, health care need, and its associated cost are, however, still substantial, and it is likely to continue to rise unless the virus is suppressed, or eliminated. In the stronger mitigation and suppression scenarios, including the scenario fitting best to data from Sweden by late April 2020, there is an obvious risk of resurgence of the epidemic unless physical distancing, shielding of the elderly, and home isolation are effectively sustained.Additional analyses indicate all-cause non COVID-19 excess mortality rises with 0.4 deaths per every reported COVID-19 death in the Stockholm area..

Medienart:	Preprint

Erscheinungsjahr:	2020
Erschienen:	2020

Enthalten in:	bioRxiv.org - (2020) vom: 11. Dez. Zur Gesamtaufnahme - year:2020

Sprache:	Englisch

Beteiligte Personen:	Sjödin, Henrik [VerfasserIn] Johansson, Anders F. [VerfasserIn] Brännström, Åke [VerfasserIn] Farooq, Zia [VerfasserIn] Kriit, Hedi Katre [VerfasserIn] Wilder-Smith, Annelies [VerfasserIn] Åström, Christofer [VerfasserIn] Thunberg, Johan [VerfasserIn] Söderquist, Mårten [VerfasserIn] Rocklöv, Joacim [VerfasserIn]

Links:	Volltext [kostenfrei]

doi:	10.1101/2020.03.20.20039594

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PPN (Katalog-ID):	XBI000814393