Mediterranean Diet and atherothrombosis biomarkers: a randomized controlled trial
ABSTRACT Scope To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals.Methods and results In 358 random volunteers from the PREDIMED trial (Prevención con Dieta Mediterránea), we assessed the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO;N=120) or nuts (MedDiet-Nuts;N=119) versus a low-fat control diet (N=119). In a secondary, observational approach, we studied whether volunteers with large increments in MedDiet adherence (>2 score points) were associated with 1-year improvements in biomarkers (relative to those worsening their adherence). The MedDiet-VOO intervention increased platelet activating factor-acetylhydrolase activity in high-density lipoproteins (HDLs) by 7.5% [95% confidence interval: 0.17; 14.8] and decreased HDL-bound α1-antitrypsin levels by 6.1% [−11.8; −0.29]. The MedDiet-Nuts one reduced non-esterified fatty acid concentrations by 9.3% [−18.1; −0.53]. Only the low-fat diet was associated with increases in platelet factor-4 and prothrombin factor1+2levels versus baseline (P=0.012 andP=0.003, respectively, according to Wilcoxon signed-rank tests). Finally, large MedDiet increments were associated with less fibrinogen (−9.5% [−18.3; −0.60]) and non-esterified fatty acid concentrations (−16.7% [−31.7; −1.74]).Conclusion Following a MedDiet improves atherothrombosis biomarkers in high cardiovascular risk individuals..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
bioRxiv.org - (2023) vom: 18. Sept. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hernáez, Álvaro [VerfasserIn] |
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| doi: |
10.1101/19001909 |
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| PPN (Katalog-ID): |
XBI000174289 |
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| 520 | |a ABSTRACT Scope To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals.Methods and results In 358 random volunteers from the PREDIMED trial (Prevención con Dieta Mediterránea), we assessed the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO;N=120) or nuts (MedDiet-Nuts;N=119) versus a low-fat control diet (N=119). In a secondary, observational approach, we studied whether volunteers with large increments in MedDiet adherence (>2 score points) were associated with 1-year improvements in biomarkers (relative to those worsening their adherence). The MedDiet-VOO intervention increased platelet activating factor-acetylhydrolase activity in high-density lipoproteins (HDLs) by 7.5% [95% confidence interval: 0.17; 14.8] and decreased HDL-bound α1-antitrypsin levels by 6.1% [−11.8; −0.29]. The MedDiet-Nuts one reduced non-esterified fatty acid concentrations by 9.3% [−18.1; −0.53]. Only the low-fat diet was associated with increases in platelet factor-4 and prothrombin factor1+2levels versus baseline (P=0.012 andP=0.003, respectively, according to Wilcoxon signed-rank tests). Finally, large MedDiet increments were associated with less fibrinogen (−9.5% [−18.3; −0.60]) and non-esterified fatty acid concentrations (−16.7% [−31.7; −1.74]).Conclusion Following a MedDiet improves atherothrombosis biomarkers in high cardiovascular risk individuals. | ||
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| 700 | 1 | |a Tresserra-Rimbau, Anna |4 aut | |
| 700 | 1 | |a Pintó, Xavier |4 aut | |
| 700 | 1 | |a Fitó, Montserrat |4 aut | |
| 700 | 1 | |a Casas, Rosa |4 aut | |
| 700 | 1 | |a Martínez-González, Miguel Ángel |4 aut | |
| 700 | 1 | |a Corella, Dolores |4 aut | |
| 700 | 1 | |a Salas-Salvadó, Jordi |4 aut | |
| 700 | 1 | |a Lapetra, José |4 aut | |
| 700 | 1 | |a Gómez-Gracia, Enrique |4 aut | |
| 700 | 1 | |a Arós, Fernando |4 aut | |
| 700 | 1 | |a Fiol, Miquel |4 aut | |
| 700 | 1 | |a Serra-Majem, Lluis |4 aut | |
| 700 | 1 | |a Ros, Emilio |4 aut | |
| 700 | 1 | |a Estruch, Ramón |4 aut | |
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