Hospitalisation risk for COVID-19 patients infected with SARS-CoV-2 variant B.1.1.7: cohort analysis
Objective: To evaluate the relationship between coronavirus disease 2019 (COVID-19) diagnosis with SARS-CoV-2 variant B.1.1.7 (also known as Variant of Concern 202012/01) and the risk of hospitalisation compared to diagnosis with wildtype SARS-CoV-2 variants. Design: Retrospective cohort, analysed using stratified Cox regression. Setting: Community-based SARS-CoV-2 testing in England, individually linked with hospitalisation data. Participants: 839,278 laboratory-confirmed COVID-19 patients, of whom 36,233 had been hospitalised within 14 days, tested between 23rd November 2020 and 31st January 2021 and analysed at a laboratory with an available TaqPath assay that enables assessment of S-gene target failure (SGTF). SGTF is a proxy test for the B.1.1.7 variant. Patient data were stratified by age, sex, ethnicity, deprivation, region of residence, and date of positive test. Main outcome measures: Hospitalisation between 1 and 14 days after the first positive SARS-CoV-2 test. Results: 27,710 of 592,409 SGTF patients (4.7%) and 8,523 of 246,869 non-SGTF patients (3.5%) had been hospitalised within 1-14 days. The stratum-adjusted hazard ratio (HR) of hospitalisation was 1.52 (95% confidence interval [CI] 1.47 to 1.57) for COVID-19 patients infected with SGTF variants, compared to those infected with non-SGTF variants. The effect was modified by age (P<0.001), with HRs of 0.93-1.21 for SGTF compared to non-SGTF patients below age 20 years, 1.29 in those aged 20-29, and 1.45-1.65 in age groups 30 years or older. Conclusions: The results suggest that the risk of hospitalisation is higher for individuals infected with the B.1.1.7 variant compared to wildtype SARS-CoV-2, likely reflecting a more severe disease. The higher severity may be specific to adults above the age of 30..
Medienart: |
Preprint |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
arXiv.org - (2021) vom: 12. Apr. Zur Gesamtaufnahme - year:2021 |
---|
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Nyberg, Tommy [VerfasserIn] |
---|
Links: |
---|
doi: |
10.1136/bmj.n1412 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
XAR020339690 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | XAR020339690 | ||
003 | DE-627 | ||
005 | 20230429065127.0 | ||
007 | cr uuu---uuuuu | ||
008 | 210414s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1136/bmj.n1412 |2 doi | |
035 | |a (DE-627)XAR020339690 | ||
035 | |a (arXiv)2104.05560 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | |a 570 |q DE-84 | |
082 | 0 | |a 510 |q DE-84 | |
100 | 1 | |a Nyberg, Tommy |e verfasserin |4 aut | |
245 | 1 | 0 | |a Hospitalisation risk for COVID-19 patients infected with SARS-CoV-2 variant B.1.1.7: cohort analysis |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Objective: To evaluate the relationship between coronavirus disease 2019 (COVID-19) diagnosis with SARS-CoV-2 variant B.1.1.7 (also known as Variant of Concern 202012/01) and the risk of hospitalisation compared to diagnosis with wildtype SARS-CoV-2 variants. Design: Retrospective cohort, analysed using stratified Cox regression. Setting: Community-based SARS-CoV-2 testing in England, individually linked with hospitalisation data. Participants: 839,278 laboratory-confirmed COVID-19 patients, of whom 36,233 had been hospitalised within 14 days, tested between 23rd November 2020 and 31st January 2021 and analysed at a laboratory with an available TaqPath assay that enables assessment of S-gene target failure (SGTF). SGTF is a proxy test for the B.1.1.7 variant. Patient data were stratified by age, sex, ethnicity, deprivation, region of residence, and date of positive test. Main outcome measures: Hospitalisation between 1 and 14 days after the first positive SARS-CoV-2 test. Results: 27,710 of 592,409 SGTF patients (4.7%) and 8,523 of 246,869 non-SGTF patients (3.5%) had been hospitalised within 1-14 days. The stratum-adjusted hazard ratio (HR) of hospitalisation was 1.52 (95% confidence interval [CI] 1.47 to 1.57) for COVID-19 patients infected with SGTF variants, compared to those infected with non-SGTF variants. The effect was modified by age (P<0.001), with HRs of 0.93-1.21 for SGTF compared to non-SGTF patients below age 20 years, 1.29 in those aged 20-29, and 1.45-1.65 in age groups 30 years or older. Conclusions: The results suggest that the risk of hospitalisation is higher for individuals infected with the B.1.1.7 variant compared to wildtype SARS-CoV-2, likely reflecting a more severe disease. The higher severity may be specific to adults above the age of 30. | ||
700 | 1 | |a Twohig, Katherine A. |e verfasserin |4 aut | |
700 | 1 | |a Harris, Ross J. |e verfasserin |4 aut | |
700 | 1 | |a Seaman, Shaun R. |e verfasserin |4 aut | |
700 | 1 | |a Flannagan, Joe |e verfasserin |4 aut | |
700 | 1 | |a Allen, Hester |e verfasserin |4 aut | |
700 | 1 | |a Charlett, Andre |e verfasserin |4 aut | |
700 | 1 | |a De Angelis, Daniela |e verfasserin |4 aut | |
700 | 1 | |a Dabrera, Gavin |e verfasserin |4 aut | |
700 | 1 | |a Presanis, Anne M. |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t arXiv.org |g (2021) vom: 12. Apr. |
773 | 1 | 8 | |g year:2021 |g day:12 |g month:04 |
856 | 4 | 0 | |u http://dx.doi.org/10.1136/bmj.n1412 |z lizenzpflichtig |3 Volltext |
856 | 4 | 0 | |u https://arxiv.org/abs/2104.05560 |z kostenfrei |3 Volltext |
912 | |a GBV_XAR | ||
912 | |a SSG-OLC-PHA | ||
951 | |a AR | ||
952 | |j 2021 |b 12 |c 04 | ||
953 | |2 045F |a 570 | ||
953 | |2 045F |a 510 |