Enhancement degree of brain metastases: correlation analysis between enhanced T2 FLAIR and vascular permeability parameters of dynamic contrast-enhanced MRI
Objectives To investigate the correlation between enhancement degrees of brain metastases on contrast-enhanced T2-fluid-attenuated inversion recovery (CE-T2 FLAIR) and vascular permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods Thirty-nine patients with brain metastases were prospectively collected. They underwent non-enhanced T2 FLAIR, DCE-MRI, CE-T2 FLAIR, and contrast-enhanced three-dimensional brain volume imaging (CE-BRAVO). Quantitative parameters of DCE-MRI were evaluated for all lesions, which included volume transfer constant ($ K^{trans} $), rate constant ($ K_{ep} $), and fractional volume of the extracellular extravascular space ($ V_{e} $). Contrast ratio (CR) and percentage increase (PI) values of all lesions on CE-T2 FLAIR were also measured. The tumor enhancement degree on CE-T2 FLAIR in relation to CE-BRAVO was visually classified as higher (group A), equal (group B), and lower (group C). Results A total of 82 brain metastases were evaluated, including 31 in group A, 19 in group B, and 32 in group C. The $ K^{trans} $ and $ K_{ep} $ were negatively correlated with the CR (ρ = − 0.551, p < 0.001 and ρ = − 0.708, p < 0.001, respectively) and PI (ρ = − 0.511, p < 0.001 and ρ = − 0.621, p < 0.001, respectively). The $ K^{trans} $ and $ K_{ep} $ of group A were significantly lower than those of group C (both p < 0.001). No significant difference was found in $ V_{e} $ among the groups (p = 0.327). Conclusions The enhancement degree of brain metastases on CE-T2 FLAIR is negatively correlated with $ K^{trans} $ and $ K_{ep} $ values, which indicate that vascular permeability parameters may play an important role in explaining the difference in enhancement between CE-T2 FLAIR and CE-BRAVO. Key Points • The enhancement degree on CE-T2 FLAIR was negatively correlated with Ktransand Kepvalues. • The vascular permeability of brain metastasis accounted for the difference in enhancement degree between CE-T2 FLAIR and CE-BRAVO. • CE-T2 FLAIR is useful for detecting brain metastases with mild disruption of the blood-brain barrier..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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| Enthalten in: |
European radiology - 31(2021), 8 vom: 13. Apr., Seite 5595-5604 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jin, Teng [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
| Anmerkungen: |
© European Society of Radiology 2020 |
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| doi: |
10.1007/s00330-020-07625-8 |
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| funding: |
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SPR044513437 |
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| 520 | |a Objectives To investigate the correlation between enhancement degrees of brain metastases on contrast-enhanced T2-fluid-attenuated inversion recovery (CE-T2 FLAIR) and vascular permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods Thirty-nine patients with brain metastases were prospectively collected. They underwent non-enhanced T2 FLAIR, DCE-MRI, CE-T2 FLAIR, and contrast-enhanced three-dimensional brain volume imaging (CE-BRAVO). Quantitative parameters of DCE-MRI were evaluated for all lesions, which included volume transfer constant ($ K^{trans} $), rate constant ($ K_{ep} $), and fractional volume of the extracellular extravascular space ($ V_{e} $). Contrast ratio (CR) and percentage increase (PI) values of all lesions on CE-T2 FLAIR were also measured. The tumor enhancement degree on CE-T2 FLAIR in relation to CE-BRAVO was visually classified as higher (group A), equal (group B), and lower (group C). Results A total of 82 brain metastases were evaluated, including 31 in group A, 19 in group B, and 32 in group C. The $ K^{trans} $ and $ K_{ep} $ were negatively correlated with the CR (ρ = − 0.551, p < 0.001 and ρ = − 0.708, p < 0.001, respectively) and PI (ρ = − 0.511, p < 0.001 and ρ = − 0.621, p < 0.001, respectively). The $ K^{trans} $ and $ K_{ep} $ of group A were significantly lower than those of group C (both p < 0.001). No significant difference was found in $ V_{e} $ among the groups (p = 0.327). Conclusions The enhancement degree of brain metastases on CE-T2 FLAIR is negatively correlated with $ K^{trans} $ and $ K_{ep} $ values, which indicate that vascular permeability parameters may play an important role in explaining the difference in enhancement between CE-T2 FLAIR and CE-BRAVO. Key Points • The enhancement degree on CE-T2 FLAIR was negatively correlated with Ktransand Kepvalues. • The vascular permeability of brain metastasis accounted for the difference in enhancement degree between CE-T2 FLAIR and CE-BRAVO. • CE-T2 FLAIR is useful for detecting brain metastases with mild disruption of the blood-brain barrier. | ||
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| 650 | 4 | |a Perfusion |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Zhang, Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiaoming |e verfasserin |4 aut | |
| 700 | 1 | |a Kong, Xiangchuang |e verfasserin |4 aut | |
| 700 | 1 | |a Makamure, Joyman |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ziwen |e verfasserin |4 aut | |
| 700 | 1 | |a Alwalid, Osamah |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Zhenwei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jing |e verfasserin |4 aut | |
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