The impact of COVID-19 on familial Mediterranean fever: a nationwide study

Abstract The study aimed to evaluate the impact of the coronavirus disease 2019 (COVID-19) in patients with familial Mediterranean fever (FMF) and to assess the relationships between FMF characteristics and severe COVID-19 outcomes such as hospitalization. The study was planned within a national network of 21 different centers. Demographics, FMF-related clinical and genetic characteristics, and COVID-19 outcomes were obtained. A total of 822 patients with FMF (mean age of 36 years) were included in the study. Fifty-nine of them (7%) had a COVID-19 diagnosis confirmed by real-time PCR test or chest CT findings. Most FMF patients with COVID-19 (58) had mild and moderate disease activity. All patients were on colchicine treatment. However, 8 of them (13.6%) were not compliant with colchicine use and 9 of them (15.3%) were colchicine resistant. Twelve FMF patients with COVID-19 were hospitalized. There were 4 patients requiring oxygen support. COVID-19 related complications were observed in 2 patients (1 thromboembolism, 1 acute respiratory distress syndrome). Hospitalized COVID-19 patients with FMF were older than non-hospitalized patients (median ages: 51 and 31 years, respectively; p: 0.002). Other FMF-related characteristics were similar between the groups. FMF-related characteristics were not found to be associated with poor outcomes in COVID-19. Thus, FMF may not be a risk factor for poor COVID-19 outcomes..

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:41

Enthalten in:

Rheumatology international - 41(2021), 8 vom: 25. Mai, Seite 1447-1455

Sprache:

Englisch

Beteiligte Personen:

Günendi, Zafer [VerfasserIn]
Yurdakul, Fatma Gül [VerfasserIn]
Bodur, Hatice [VerfasserIn]
Cengiz, Ahmet Kıvanç [VerfasserIn]
Uçar, Ülkü [VerfasserIn]
Çay, Hasan Fatih [VerfasserIn]
Şen, Nesrin [VerfasserIn]
Keskin, Yaşar [VerfasserIn]
Gürer, Gülcan [VerfasserIn]
Melikoğlu, Meltem Alkan [VerfasserIn]
Altıntaş, Duygu [VerfasserIn]
Deveci, Hülya [VerfasserIn]
Baykul, Merve [VerfasserIn]
Nas, Kemal [VerfasserIn]
Çevik, Remzi [VerfasserIn]
Karahan, Ali Yavuz [VerfasserIn]
Toprak, Murat [VerfasserIn]
Ketenci, Sertaç [VerfasserIn]
Nayimoğlu, Mehmet [VerfasserIn]
Sezer, İlhan [VerfasserIn]
Demir, Ali Nail [VerfasserIn]
Ecesoy, Hilal [VerfasserIn]
Duruöz, Mehmet Tuncay [VerfasserIn]
Yurdakul, Ozan Volkan [VerfasserIn]
Sarıfakıoğlu, Ayşe Banu [VerfasserIn]
Ataman, Şebnem [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.83

Themen:

COVID-19
Colchicine
Familial Mediterranean fever
Hospitalization
Poor outcomes
Rheumatic diseases

Anmerkungen:

© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021

doi:

10.1007/s00296-021-04892-6

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

SPR04444267X