Emerging role of 18F-FDG PET/CT in Castleman disease: a review

Abstract Castleman disease (CD) describes a group of rare hematologic conditions involving lymphadenopathy with characteristic histopathology and a spectrum of clinical abnormalities. CD is divided into localized or unicentric CD (UCD) and multicentric CD (MCD) by imaging. MCD is further divided based on etiological driver into human herpesvirus-8-associated MCD, POEMS-associated MCD, and idiopathic MCD. There is notable heterogeneity across MCD, but increased level of pro-inflammatory cytokines, particularly interleukin-6, is an established disease driver in a portion of patients. FDG-PET/CT can help determine UCD versus MCD, evaluate for neoplastic conditions that can mimic MCD clinico-pathologically, and monitor therapy responses. CD requires more robust characterization, earlier diagnosis, and an accurate tool for both monitoring and treatment response evaluation; FDG-PET/CT is particularly suited for this. Moving forward, future prospective studies should further characterize the use of FDG-PET/CT in CD and specifically explore the utility of global disease assessment and dual time point imaging. Trial registration ClinicalTrials.gov, NCT02817997, Registered 29 June 2016, https://clinicaltrials.gov/ct2/show/NCT02817997.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:12

Enthalten in:

Insights into imaging - 12(2021), 1 vom: 11. März

Sprache:

Englisch

Beteiligte Personen:

Koa, Benjamin [VerfasserIn]
Borja, Austin J. [VerfasserIn]
Aly, Mahmoud [VerfasserIn]
Padmanabhan, Sayuri [VerfasserIn]
Tran, Joseph [VerfasserIn]
Zhang, Vincent [VerfasserIn]
Rojulpote, Chaitanya [VerfasserIn]
Pierson, Sheila K. [VerfasserIn]
Tamakloe, Mark-Avery [VerfasserIn]
Khor, Johnson S. [VerfasserIn]
Werner, Thomas J. [VerfasserIn]
Fajgenbaum, David C. [VerfasserIn]
Alavi, Abass [VerfasserIn]
Revheim, Mona-Elisabeth [VerfasserIn]

Links:

Volltext [kostenfrei]

Themen:

Castleman disease
Fluorodeoxyglucose F18
HIV
Interleukin-6
Positron emission tomography/computed tomography

doi:

10.1186/s13244-021-00963-1

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

SPR043466737