The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients

Objective This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb 13, 2020. Methods The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. Results COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir + ribavirin. Conclusions Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection..

Media Type:

Electronic Article

Year of Publication:

2020

Publication:

2020

Contained In:

Inflammation research - 69(2020), 6 vom: 29. März, Seite 599-606

Language:

English

Contributors:

Yuan, Jing [Author]
Zou, Rougrong [Author]
Zeng, Lijiao [Author]
Kou, Shanglong [Author]
Lan, Jianfeng [Author]
Li, Xiaohe [Author]
Liang, Yanhua [Author]
Ding, Xiaoyan [Author]
Tan, Guoyu [Author]
Tang, Shenghong [Author]
Liu, Lei [Author]
Liu, Yingxia [Author]
Pan, Yanchao [Author]
Wang, Zhaoqin [Author]

Links:

Volltext [Lizenzpflichtig]

Keywords:

CK
COVID-19
Clearance ratio
LDH

doi:

10.1007/s00011-020-01342-0

PPN (Catalogue-ID):

SPR039618692