The impact of low-dose versus high-dose antibiotic prophylaxis regimens on surgical site infection rates after cesarean delivery
Objective The objective of this study was to determine if high-dose antibiotic prophylaxis with cefazolin decreases the risk of surgical site infection (SSI) after a cesarean delivery. Methods We performed a retrospective cohort study of women who underwent a cesarean section. Two preoperative antibiotic regimens were compared: low dose versus high dose. The primary outcome was SSI. A sample size of 343 patients per group was calculated for a 50% reduction in risk for SSI. Results Seven hundred and thirty women were included with an incidence of SSI of 5%. Women who received the high-dose antibiotic regimen had lower rates of risk factors for SSI. The only exception was skin incision closure with staples. The rate of SSI did not differ between the low-dose and high-dose groups, even after adjusting for confounding variables [aOR 1.78, 95% CI (0.82–3.9)]. Conclusions Higher doses of antibiotic prophylaxis did not decrease the rates of SSI after cesarean delivery..
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E-Artikel |
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Erscheinungsjahr: |
2019 |
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Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:301 |
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Enthalten in: |
Archives of gynecology and obstetrics - 301(2019), 1 vom: 06. Dez., Seite 69-73 |
Sprache: |
Englisch |
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Beteiligte Personen: |
La Rosa, Mauricio [VerfasserIn] |
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Volltext [lizenzpflichtig] |
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Themen: |
doi: |
10.1007/s00404-019-05370-y |
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PPN (Katalog-ID): |
SPR005144590 |
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520 | |a Objective The objective of this study was to determine if high-dose antibiotic prophylaxis with cefazolin decreases the risk of surgical site infection (SSI) after a cesarean delivery. Methods We performed a retrospective cohort study of women who underwent a cesarean section. Two preoperative antibiotic regimens were compared: low dose versus high dose. The primary outcome was SSI. A sample size of 343 patients per group was calculated for a 50% reduction in risk for SSI. Results Seven hundred and thirty women were included with an incidence of SSI of 5%. Women who received the high-dose antibiotic regimen had lower rates of risk factors for SSI. The only exception was skin incision closure with staples. The rate of SSI did not differ between the low-dose and high-dose groups, even after adjusting for confounding variables [aOR 1.78, 95% CI (0.82–3.9)]. Conclusions Higher doses of antibiotic prophylaxis did not decrease the rates of SSI after cesarean delivery. | ||
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700 | 1 | |a Saad, Antonio F. |e verfasserin |4 aut | |
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