The impact of low-dose versus high-dose antibiotic prophylaxis regimens on surgical site infection rates after cesarean delivery

Objective The objective of this study was to determine if high-dose antibiotic prophylaxis with cefazolin decreases the risk of surgical site infection (SSI) after a cesarean delivery. Methods We performed a retrospective cohort study of women who underwent a cesarean section. Two preoperative antibiotic regimens were compared: low dose versus high dose. The primary outcome was SSI. A sample size of 343 patients per group was calculated for a 50% reduction in risk for SSI. Results Seven hundred and thirty women were included with an incidence of SSI of 5%. Women who received the high-dose antibiotic regimen had lower rates of risk factors for SSI. The only exception was skin incision closure with staples. The rate of SSI did not differ between the low-dose and high-dose groups, even after adjusting for confounding variables [aOR 1.78, 95% CI (0.82–3.9)]. Conclusions Higher doses of antibiotic prophylaxis did not decrease the rates of SSI after cesarean delivery..

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:301

Enthalten in:

Archives of gynecology and obstetrics - 301(2019), 1 vom: 06. Dez., Seite 69-73

Sprache:

Englisch

Beteiligte Personen:

La Rosa, Mauricio [VerfasserIn]
Omere, Chasey [VerfasserIn]
Redfern, Tiffany [VerfasserIn]
Abdelwahab, Mahmoud [VerfasserIn]
Spencer, Nicholas [VerfasserIn]
Villarreal, Josephine [VerfasserIn]
Olson, Gayle [VerfasserIn]
Saade, George R. [VerfasserIn]
Saad, Antonio F. [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.92

Themen:

Antibiotics
Cesarean
Infection
Pregnancy
Prophylaxis
Wound

doi:

10.1007/s00404-019-05370-y

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

SPR005144590