Antioxidant, Brine Shrimp Lethality, and Antiproliferative Properties of Gel and Leaf Extracts of Aloe schweinfurthii and Aloe vera

Leaf and gel extracts of Aloe schweinfurthii and A. vera were subjected to in vitro antioxidant assay using 2,2-diphennyl-1-picryl hydrazyl (DPPH), brine shrimp lethality bioassay, and cytotoxicity using the MTT assay with two human cancer cell lines: Rd and Hep-2c. Extracts of A. schweinfurthii gel had IC 50 values of 44.59; A. vera gel, 41.48, and A. vera leaf, 38.84 µg.mL -1 , had similar DPPH radical-scavenging properties and were more active than A. schweinfurthii leaf. Ascorbic acid had an IC 50 of 9.26 ± 0.14 µg.mL -1 . Aloe vera leaf (LC 50 = 325 ± 5.38 µg.mL -1 ) was more active than the other three extracts in the BSL assay. The gel extracts of A. schweinfurthii (CC 50 = 4.06 µg.mL -1 on Rd and 9.00 µg.mL -1 on Hep-2c) and A. vera (CC 50 = 4.31 µg.mL -1 on Rd, 9.06 µg.mL -1 on Hep-2c) elicited similar and more potent cytotoxicity comparable to cyclophosphamide, with CC 50 = 2.2 µg.mL -1 on Rd and 2.66 µg.mL -1 on Hep-2c. Leaf extracts were less active than gel extracts. This study showed that A. schweinfurthii gel, A. vera gel and leaf had weak DPPH activity which were similar. Aloe vera and A. schweinfurthii did not elicit potent cytotoxicity in BSL assay. The gels from both Aloe species displayed antipoliferative activity on Rd and Hep-2c, two human cell cancer lines..

Medienart:

Artikel

Erscheinungsjahr:

2017

Erschienen:

2017

Enthalten in:

Zur Gesamtaufnahme - volume:23

Enthalten in:

Journal of herbs, spices & medicinal plants - 23(2017), 4, Seite 263

Sprache:

Englisch

Beteiligte Personen:

Salawu, Kayode Muritala [VerfasserIn]
Ajaiyeoba, Edith Oriabure [Sonstige Person]
Ogbole, Omonike Oluyemisi [Sonstige Person]
Adeniji, Johnson Adekunle [Sonstige Person]
Faleye, Temitope Cephas [Sonstige Person]
Agunu, Abdulkarim [Sonstige Person]

Links:

Volltext
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BKL:

42.38

44.00

Themen:

Aloe
Antioxidants
Ascorbic acid
Assaying
BSL
Bioassays
Cancer
Cyclophosphamide
Cytotoxicity
DPPH radical scavenging
Gels
Herbal medicine
Leaves
Lethality
Rd and Hep-2c human cancer cell lines
Salt water
Toxicity
Tumor cell lines

doi:

10.1080/10496475.2017.1318328

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC1998213633