Steroid Hybrid Systems: New Molecular Entities with Potential Therapeutical Spectrum
Background: Hybrid systems in recent times are drawing considerable attention in the area of drug development as many of such systems are now becoming drug targets in diverse therapeutical applications. In our recent work, we reported a Microwave (MW) irradiated Ugi-4 component reaction (Ugi-4CR) in synthesizing a number of steroid-amino acid conjugates based on seco-steroid hydroxyacids (A, B & D ring cleavage) in an expedited way giving very high yield of hybrid products. Considering the importance of steroid based hybrid molecules coupled with advantages of MW energy in organic synthesis, we report here a very high yield synthesis of another class of important hybrid system based on aminosteroids by the application of MW-irradiated Ugi-4CR in expedited way. Methods: For the first time author synthesized Steroid-amino acid conjugated based on steroidal amines by using microwave irradiated Ugi-4CR. Results: The diverse synthesis of Steroid-amino acid conjugated would undoubtedly find a significant place in organic synthesis as steroid-peptide conjugates are currently gaining considerable importance because of their diverse biological properties. Conclusion: The method may also be helpful in promoting green technology in organic synthesis. The reaction proceeds smoothly requiring very short duration of time giving very high yield of Ugi-4CR coupling products. Further work on the biological evaluation of various steroid-amino acid conjugates synthesized is in progress and the results will be published in due course of time..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Current drug therapy - 12(2017), 1, Seite 3-22 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Preetismita Borah [VerfasserIn] |
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| 520 | |a Background: Hybrid systems in recent times are drawing considerable attention in the area of drug development as many of such systems are now becoming drug targets in diverse therapeutical applications. In our recent work, we reported a Microwave (MW) irradiated Ugi-4 component reaction (Ugi-4CR) in synthesizing a number of steroid-amino acid conjugates based on seco-steroid hydroxyacids (A, B & D ring cleavage) in an expedited way giving very high yield of hybrid products. Considering the importance of steroid based hybrid molecules coupled with advantages of MW energy in organic synthesis, we report here a very high yield synthesis of another class of important hybrid system based on aminosteroids by the application of MW-irradiated Ugi-4CR in expedited way. Methods: For the first time author synthesized Steroid-amino acid conjugated based on steroidal amines by using microwave irradiated Ugi-4CR. Results: The diverse synthesis of Steroid-amino acid conjugated would undoubtedly find a significant place in organic synthesis as steroid-peptide conjugates are currently gaining considerable importance because of their diverse biological properties. Conclusion: The method may also be helpful in promoting green technology in organic synthesis. The reaction proceeds smoothly requiring very short duration of time giving very high yield of Ugi-4CR coupling products. Further work on the biological evaluation of various steroid-amino acid conjugates synthesized is in progress and the results will be published in due course of time. | ||
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