Prodrugs to Codrugs
Background: The Carrier linked prodrug as per literature is known to be a pharmacologically inactive chemical derivative and could be used to change the physicochemical properties of compounds. Codrugs is a type of carrier linked prodrug, and consist of two usually synergistic drugs or moieties attached to each other. Objective: synthesis of codrug consists of two pharmacologically active compounds coupled together where one drug is the carrier for the other and vice versa. Result: It is a very beneficial area of research and its admittance in human therapy has given successful results clinically as well as therapeutically. Conclusion: The emphasis is carried on Benorylate, the Codrug of aspirin and paracetamol for improved anti-inflammatory and analgesic activity. The article also takes a review of the various applications of Codrugs and the development in this field during the last few decades..
Medienart: |
Artikel |
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Erscheinungsjahr: |
2017 |
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Erschienen: |
2017 |
Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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Enthalten in: |
Current drug therapy - 12(2017), 1, Seite 29-36 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Deepali Gangrade [VerfasserIn] |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
OLC1995566802 |
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520 | |a Background: The Carrier linked prodrug as per literature is known to be a pharmacologically inactive chemical derivative and could be used to change the physicochemical properties of compounds. Codrugs is a type of carrier linked prodrug, and consist of two usually synergistic drugs or moieties attached to each other. Objective: synthesis of codrug consists of two pharmacologically active compounds coupled together where one drug is the carrier for the other and vice versa. Result: It is a very beneficial area of research and its admittance in human therapy has given successful results clinically as well as therapeutically. Conclusion: The emphasis is carried on Benorylate, the Codrug of aspirin and paracetamol for improved anti-inflammatory and analgesic activity. The article also takes a review of the various applications of Codrugs and the development in this field during the last few decades. | ||
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