Optimal Volume of Administration of Intranasal Midazolam in Children: A Randomized Clinical Trial

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.annemergmed.2016.08.450 Byline: Daniel S. Tsze (a), Maria Ieni (a), Daniel B. Fenster (a), John Babineau (a), Joshua Kriger (b), Bruce Levin (b), Peter S. Dayan (a) Abstract: The optimal intranasal volume of administration for achieving timely and effective sedation in children is unclear. We aimed to compare clinical outcomes relevant to procedural sedation associated with using escalating volumes of administration to administer intranasal midazolam. Author Affiliation: (a) Department of Pediatrics, Division of Pediatric Emergency Medicine, Columbia University College of Physicians and Surgeons, New York, NY (b) Department of Biostatistics, Columbia University Medical Center, New York, NY Article History: Received 16 April 2016; Revised 22 July 2016; Revised 9 August 2016; Revised 13 August 2016; Accepted 22 August 2016 Article Note: (footnote) Please see page 601 for the Editor's Capsule Summary of this article., Supervising editors: Jocelyn Gravel, MD; Steven M. Green, MD, Author contributions: DST and PSD conceptualized the study, designed the trial, and obtained research funding. DST supervised the conduct of the trial and data collection and drafted the article. DST, MI, DBF, and JB undertook recruitment of participating patients and viewed and analyzed the video recordings. JK and BL provided statistical advice on study design and managed the data, including quality control. DST, JK, and BL conducted the statistical analyses for the study. All authors contributed substantially to article revision. DST takes responsibility for the paper as a whole., Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The authors have stated that no such relationships exist. This publication was supported by the American Academy of Pediatrics Section on Emergency Medicine Ken Graff Young Investigator Award. This publication was also supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant Number UL1TR000040. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health., Trial registration number: NCT01948908 , A feedback survey is available with each research article published on the Web at www.annemergmed.com., A podcast for this article is available at www.annemergmed.com..

Medienart:

Artikel

Erscheinungsjahr:

2016

Erschienen:

2016

Enthalten in:

Zur Gesamtaufnahme - volume:69

Enthalten in:

Annals of emergency medicine - 69(2016), 5

Sprache:

Englisch

Beteiligte Personen:

Tsze, Daniel S [VerfasserIn]
Ieni, Maria [Sonstige Person]
Fenster, Daniel B [Sonstige Person]
Babineau, John [Sonstige Person]
Kriger, Joshua [Sonstige Person]
Levin, Bruce [Sonstige Person]
Dayan, Peter S [Sonstige Person]

Links:

Volltext

BKL:

44.00

Themen:

Clinical trials
Emergency medicine
Medical societies
Midazolam

doi:

10.1016/j.annemergmed.2016.08.450

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC1994218819