The histopathologic type predicts survival of patients with ampullary carcinoma after resection: A meta-analysis
Objectives The results of studies on the prognostic value of histopathologic differentiation of the intestinal and pancreatobiliary types of ampullary carcinoma after resection are conflicting. A meta-analysis was undertaken to investigate this issue. Methods A systematic literature search was performed to identify articles published from January 2000 to August 2016. Data were pooled for meta-analysis using Review Manager 5.3. Results Twenty three retrospective studies involving a total of 2234 patients were identified for inclusion, of whom 1021 (45.7%) had intestinal type tumors and 899 (40.2%) had pancreaticobiliary type tumors. Patients with the pancreaticobiliary type had high rates of poor tumor differentiation (P< 0.001), lymph node metastasis (P< 0.001), vascular invasion (P< 0.001), perineural invasion (P< 0.001), and positive resection margins (P= 0.004), as compared with those with the intestinal type. The pancreaticobiliary type predicted a worse overall survival (hazard ratio [HR] 1.84, 95% CI 1.49-2.27;P< 0.001) and disease-free survival (HR 1.93, 95% CI 1.23-3.01;P= 0.004). Conclusion The histopathologic type has major impact on survival in patients with ampullary carcinoma after resection, and the pancreaticobiliary type reflects a more aggressive tumor biology and is associated with worse survival..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
|---|---|
| Enthalten in: |
Pancreatology - 17(2017), 2, Seite 273 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Zhou, Yanming [VerfasserIn] |
|---|
| Links: |
|---|
| BKL: | |
|---|---|
| Themen: |
Lymphatic system |
| doi: |
10.1016/j.pan.2017.01.007 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC1993573216 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1993573216 | ||
| 003 | DE-627 | ||
| 005 | 20230513222900.0 | ||
| 007 | tu | ||
| 008 | 170512s2017 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.pan.2017.01.007 |2 doi | |
| 028 | 5 | 2 | |a PQ20170721 |
| 035 | |a (DE-627)OLC1993573216 | ||
| 035 | |a (DE-599)GBVOLC1993573216 | ||
| 035 | |a (PRQ)c1889-d4433e94cb57f977762a473227cfa843b1988d3f522985adfd13de21a554c32c0 | ||
| 035 | |a (KEY)0447439220170000017000200273histopathologictypepredictssurvivalofpatientswitha | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q DNB |
| 084 | |a 44.89 |2 bkl | ||
| 084 | |a 44.87 |2 bkl | ||
| 100 | 1 | |a Zhou, Yanming |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The histopathologic type predicts survival of patients with ampullary carcinoma after resection: A meta-analysis |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a Objectives The results of studies on the prognostic value of histopathologic differentiation of the intestinal and pancreatobiliary types of ampullary carcinoma after resection are conflicting. A meta-analysis was undertaken to investigate this issue. Methods A systematic literature search was performed to identify articles published from January 2000 to August 2016. Data were pooled for meta-analysis using Review Manager 5.3. Results Twenty three retrospective studies involving a total of 2234 patients were identified for inclusion, of whom 1021 (45.7%) had intestinal type tumors and 899 (40.2%) had pancreaticobiliary type tumors. Patients with the pancreaticobiliary type had high rates of poor tumor differentiation (P< 0.001), lymph node metastasis (P< 0.001), vascular invasion (P< 0.001), perineural invasion (P< 0.001), and positive resection margins (P= 0.004), as compared with those with the intestinal type. The pancreaticobiliary type predicted a worse overall survival (hazard ratio [HR] 1.84, 95% CI 1.49-2.27;P< 0.001) and disease-free survival (HR 1.93, 95% CI 1.23-3.01;P= 0.004). Conclusion The histopathologic type has major impact on survival in patients with ampullary carcinoma after resection, and the pancreaticobiliary type reflects a more aggressive tumor biology and is associated with worse survival. | ||
| 650 | 4 | |a Surgery | |
| 650 | 4 | |a Meta-analysis | |
| 650 | 4 | |a Pancreatic cancer | |
| 650 | 4 | |a Studies | |
| 650 | 4 | |a Medical prognosis | |
| 650 | 4 | |a Mutation | |
| 650 | 4 | |a Lymphatic system | |
| 650 | 4 | |a Metastasis | |
| 700 | 1 | |a Li, Dianqi |4 oth | |
| 700 | 1 | |a Wu, Lupeng |4 oth | |
| 700 | 1 | |a Si, Xiaoying |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Pancreatology |d Amsterdam [u.a.] : Elsevier, 2001 |g 17(2017), 2, Seite 273 |w (DE-627)333810562 |w (DE-600)2056680-3 |w (DE-576)095238255 |x 1424-3903 |7 nnns |
| 773 | 1 | 8 | |g volume:17 |g year:2017 |g number:2 |g pages:273 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1016/j.pan.2017.01.007 |3 Volltext |
| 856 | 4 | 2 | |u https://search.proquest.com/docview/1884247391 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a GBV_ILN_4219 | ||
| 936 | b | k | |a 44.89 |q AVZ |
| 936 | b | k | |a 44.87 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 17 |j 2017 |e 2 |h 273 | ||