Analgesic, Anti-inflammatory, and Antipyretic Activities of Hydroethanolic Stem Bark Extract of Albizia glaberrima
The acetic acid-induced writhing, formalin, hot-plate (analgesic); carrageenan- and egg albumin-induced paw edema, formaldehyde-induced arthritis inflammation (anti-inflammatory); yeast-, turpentine-, and 2,4-DNP (dinitrophenol)-induced hyperthermia (antipyretic) tests were used to investigate the bioactivities of the hydroethanolic stem bark extract of Albizia glaberrima (AG) in rodents. AG (50-400 mg.kg -1 , p.o.) inhibited manifestation of writhing in the acetic acid-induced writhing test and prolonged the reaction time in the formalin and hot-plate tests; inhibited edema development in the carrageenan-, egg albumin-induced paw edema, and formaldehyde-induced arthritis inflammation tests; and elicited dose-dependent inhibition of temperature elevation in the yeast-, turpentine-, and 2,4-DNP-induced hyperthermia models. The effects of the extract at the most effective dose, 400 mg.kg -1 , were comparable to those of the standard drugs (acetylsalicylic acid, morphine, indomethacin, and chlorpheniramine) used. Findings suggest that the demonstrated analgesic, anti-inflammatory, and antipyretic activities of the hydroethanolic stem bark extract of A. glaberrima were mediated through peripheral and central mechanisms..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Journal of herbs, spices & medicinal plants - 23(2017), 1, Seite 44-67 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ogbiti, Victoria Modupe [VerfasserIn] |
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| Links: |
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| BKL: | |
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| Themen: |
Analgesics |
| doi: |
10.1080/10496475.2016.1260670 |
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| Förderinstitution / Projekttitel: |
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OLC1989337279 |
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| 245 | 1 | 0 | |a Analgesic, Anti-inflammatory, and Antipyretic Activities of Hydroethanolic Stem Bark Extract of Albizia glaberrima |
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| 520 | |a The acetic acid-induced writhing, formalin, hot-plate (analgesic); carrageenan- and egg albumin-induced paw edema, formaldehyde-induced arthritis inflammation (anti-inflammatory); yeast-, turpentine-, and 2,4-DNP (dinitrophenol)-induced hyperthermia (antipyretic) tests were used to investigate the bioactivities of the hydroethanolic stem bark extract of Albizia glaberrima (AG) in rodents. AG (50-400 mg.kg -1 , p.o.) inhibited manifestation of writhing in the acetic acid-induced writhing test and prolonged the reaction time in the formalin and hot-plate tests; inhibited edema development in the carrageenan-, egg albumin-induced paw edema, and formaldehyde-induced arthritis inflammation tests; and elicited dose-dependent inhibition of temperature elevation in the yeast-, turpentine-, and 2,4-DNP-induced hyperthermia models. The effects of the extract at the most effective dose, 400 mg.kg -1 , were comparable to those of the standard drugs (acetylsalicylic acid, morphine, indomethacin, and chlorpheniramine) used. Findings suggest that the demonstrated analgesic, anti-inflammatory, and antipyretic activities of the hydroethanolic stem bark extract of A. glaberrima were mediated through peripheral and central mechanisms. | ||
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