Classical and Non-Classical Thyroid Hormone Intracellular Pathways Involved in T Lymphoma Growth
Thyroid hormones (THs) are important regulators of cell physiology. They are essential for the normal development and growth of mammals, especially for the neural differentiation and the regulation of the metabolism and the immune system. THs also induce the proliferation of several cell types. In human and murine T cell lymphomas (TCL) this effect involves the participation of genomic and nongenomic mechanisms as it was described by the use of free THs and non-cell permeable THs coupled to agarose (TH-ag). The classic actions of thyroid hormones involve the alteration of gene transcription via specific nuclear receptors. The discovery of other effects, independent of this classic mechanism, characterizes a new and non-classic mechanism that involves different signaling pathways. Both, free THs and TH-ag, activate protein kinase C, extracellular signalregulated kinases and NF-kB and they increase the intracellular calcium levels. However, only the preincubation of T cells with free THs leads to an increased intracellular content of signaling enzymes. T lymphomas display high expression levels of both, the TH nuclear receptors (TRs) and the putative membrane receptor for THs, the integrin αvβ3, which has been demonstrated to be responsible for THs non-genomic actions. Here, we reviewed the mechanisms involved in THs modulation of the lymphocyte physiology, analyzing the interplay between genomic and nongenomic actions in T cells and its contribution in the development of lymphomas..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
|---|---|
| Enthalten in: |
Immunology, endocrine & metabolic agents in medicinal chemistry - 15(2015), 1, Seite 37-42 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
L.B. Arcos, Maria [VerfasserIn] |
|---|
| Links: |
|---|
| BKL: |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
OLC1986720942 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC1986720942 | ||
| 003 | DE-627 | ||
| 005 | 20230518124702.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170131s2015 xx |||||o 00| ||eng c | ||
| 028 | 5 | 2 | |a fidpha_zeitschriften_20170130.pp |
| 035 | |a (DE-627)OLC1986720942 | ||
| 035 | |a (DE-599)GBVOLC1986720942 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |
| 084 | |a PHARM |2 fid | ||
| 084 | |a 44.40 |2 bkl | ||
| 100 | 1 | |a L.B. Arcos, Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Classical and Non-Classical Thyroid Hormone Intracellular Pathways Involved in T Lymphoma Growth |
| 264 | 1 | |c 2015 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Thyroid hormones (THs) are important regulators of cell physiology. They are essential for the normal development and growth of mammals, especially for the neural differentiation and the regulation of the metabolism and the immune system. THs also induce the proliferation of several cell types. In human and murine T cell lymphomas (TCL) this effect involves the participation of genomic and nongenomic mechanisms as it was described by the use of free THs and non-cell permeable THs coupled to agarose (TH-ag). The classic actions of thyroid hormones involve the alteration of gene transcription via specific nuclear receptors. The discovery of other effects, independent of this classic mechanism, characterizes a new and non-classic mechanism that involves different signaling pathways. Both, free THs and TH-ag, activate protein kinase C, extracellular signalregulated kinases and NF-kB and they increase the intracellular calcium levels. However, only the preincubation of T cells with free THs leads to an increased intracellular content of signaling enzymes. T lymphomas display high expression levels of both, the TH nuclear receptors (TRs) and the putative membrane receptor for THs, the integrin αvβ3, which has been demonstrated to be responsible for THs non-genomic actions. Here, we reviewed the mechanisms involved in THs modulation of the lymphocyte physiology, analyzing the interplay between genomic and nongenomic actions in T cells and its contribution in the development of lymphomas. | ||
| 700 | 1 | |a Sterle, Helena |e verfasserin |4 aut | |
| 700 | 1 | |a Cayrol, Florencia |e verfasserin |4 aut | |
| 700 | 1 | |a C.D. Flaque, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Valli, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a A. Paulazo, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a J. Klecha, Alicia |e verfasserin |4 aut | |
| 700 | 1 | |a A. Cremaschi, Graciela |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Immunology, endocrine & metabolic agents in medicinal chemistry |d San Francisco, Calif. : Bentham Science Publ., 2006 |g 15(2015), 1, Seite 37-42 |w (DE-627)507526643 |w (DE-600)2221719-8 |w (DE-576)435514261 |x 1871-5222 |7 nnns |
| 773 | 1 | 8 | |g volume:15 |g year:2015 |g number:1 |g pages:37-42 |
| 856 | 4 | 0 | |u http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1871-5222&volume=15&issue=1&spage=37 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a FID-PHARM | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a SSG-OPC-PHA | ||
| 912 | |a GBV_ILN_20 | ||
| 936 | b | k | |a 44.40 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 15 |j 2015 |e 1 |h 37-42 | ||