Identification of Degradation Products of Cefoselis Sulfate by HPLC-ESI-Quadrupole Time-Of-Flight-Mass Spectrometry in Aqueous Solutions
Six degradation products of cefoselis sulfate in aqueous solutions were identified. For that purpose chromatographic system consisting of Kinetex, C18, 100A, 100 2.1 mm, particle size 5 μm column, mobile phase: acetonitrile - 0.1% formic acid (5:95 V/V) and a hybrid ESI-Q-TOF mass spectrometer was used. Masses of degradation products with high accuracy (0.09 - 4.64 ppm) were found. Following formulas were obtained: 128.08243 (C5H10N3O), 243.05471 (C8H10N4O3S), 370.06338 (C13H16N5O4S2), 414.05324 (C14H16N5O6S2), 451.13191 (C17H23N8O3S2), 479.12777 (C18H22N8O4S2) and 523.11859 (C19H23N8O6S2) - cefoselis sulfate. Degradation pathways of cefoselis sulfate in aqueous solutions were suggested..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Current pharmaceutical analysis - 13(2017), 1, Seite 26-30 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zalewski, Przemyslaw [VerfasserIn] |
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| Links: |
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| PPN (Katalog-ID): |
OLC1986715914 |
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| 245 | 1 | 0 | |a Identification of Degradation Products of Cefoselis Sulfate by HPLC-ESI-Quadrupole Time-Of-Flight-Mass Spectrometry in Aqueous Solutions |
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| 520 | |a Six degradation products of cefoselis sulfate in aqueous solutions were identified. For that purpose chromatographic system consisting of Kinetex, C18, 100A, 100 2.1 mm, particle size 5 μm column, mobile phase: acetonitrile - 0.1% formic acid (5:95 V/V) and a hybrid ESI-Q-TOF mass spectrometer was used. Masses of degradation products with high accuracy (0.09 - 4.64 ppm) were found. Following formulas were obtained: 128.08243 (C5H10N3O), 243.05471 (C8H10N4O3S), 370.06338 (C13H16N5O4S2), 414.05324 (C14H16N5O6S2), 451.13191 (C17H23N8O3S2), 479.12777 (C18H22N8O4S2) and 523.11859 (C19H23N8O6S2) - cefoselis sulfate. Degradation pathways of cefoselis sulfate in aqueous solutions were suggested. | ||
| 700 | 1 | |a Skibinski, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Talaczynska, Alicja |e verfasserin |4 aut | |
| 700 | 1 | |a Paczkowska, Magdalena |e verfasserin |4 aut | |
| 700 | 1 | |a Cielecka-Piontek, Judyta |e verfasserin |4 aut | |
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