AR‐12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication

OSU‐03012 inhibits HSP90 and HSP70 family chaperones which causes enhanced basal levels of endoplasmic reticulum stress and autophagic flux. These biological events collectively result in the destabilization of viral receptors and viral proteins resulting in their degradation. The roles of different chaperones in the replicative potential of viruses as diverse as Measles, HIV, Junin and Ebola has been defined; OSU‐03012 prevents the replication of multiple protease inhibitor resistant strains of HIV. In a rabbit hemorrhagic fever model system, transient exposure to OSU‐03012 reduced animal death and liver damage by over 50%, arguing that the drug has significant anti‐viral activity in vivo..

Medienart:

Artikel

Erscheinungsjahr:

2016

Erschienen:

2016

Enthalten in:

Zur Gesamtaufnahme - volume:231

Enthalten in:

Journal of cellular physiology - 231(2016), 10, Seite 2286-2302

Sprache:

Englisch

Beteiligte Personen:

Booth, Laurence [VerfasserIn]
Roberts, Jane L [Sonstige Person]
Ecroyd, Heath [Sonstige Person]
Tritsch, Sarah R [Sonstige Person]
Bavari, Sina [Sonstige Person]
Reid, St. Patrick [Sonstige Person]
Proniuk, Stefan [Sonstige Person]
Zukiwski, Alexander [Sonstige Person]
Jacob, Abraham [Sonstige Person]
Sepúlveda, Claudia S [Sonstige Person]
Giovannoni, Federico [Sonstige Person]
García, Cybele C [Sonstige Person]
Damonte, Elsa [Sonstige Person]
González‐Gallego, Javier [Sonstige Person]
Tuñón, María J [Sonstige Person]
Dent, Paul [Sonstige Person]

Links:

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www.ncbi.nlm.nih.gov
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doi:

10.1002/jcp.25431

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC1982555807