4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase
A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylesterase inhibitors were identified..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 26(2016), 4, Seite 1184 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Han, Qiang [VerfasserIn] |
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| Links: |
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| Förderinstitution / Projekttitel: |
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OLC1972155326 |
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| 520 | |a A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylesterase inhibitors were identified. | ||
| 540 | |a Nutzungsrecht: Copyright © 2016 Elsevier Ltd. All rights reserved. | ||
| 700 | 1 | |a Terranova, Kristen M |4 oth | |
| 700 | 1 | |a Xu, Xiaolian |4 oth | |
| 700 | 1 | |a Pabba, Praveen K |4 oth | |
| 700 | 1 | |a Schmidt, James M |4 oth | |
| 700 | 1 | |a Healy, Jason P |4 oth | |
| 700 | 1 | |a Tarver, Jr, James E |4 oth | |
| 700 | 1 | |a Thompson, Andrea Y |4 oth | |
| 700 | 1 | |a Barbosa, Joseph |4 oth | |
| 700 | 1 | |a Gardyan, Michael W |4 oth | |
| 700 | 1 | |a Brommage, Robert |4 oth | |
| 700 | 1 | |a Carson, Kenneth G |4 oth | |
| 700 | 1 | |a Wilson, Alan G E |4 oth | |
| 700 | 1 | |a Mabon, Ross |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Bioorganic & medicinal chemistry letters |d Amsterdam [u.a.] : Elsevier, 1991 |g 26(2016), 4, Seite 1184 |w (DE-627)130952400 |w (DE-600)1063195-1 |w (DE-576)025097946 |x 0960-894X |7 nnns |
| 773 | 1 | 8 | |g volume:26 |g year:2016 |g number:4 |g pages:1184 |
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