Infection control preparedness for human infection with influenza A H7N9 in Hong Kong
OBJECTIVE To assess the effectiveness of infection control preparedness for human infection with influenza A H7N9 in Hong Kong. DESIGN A descriptive study of responses to the emergence of influenza A H7N9. SETTING A university-affiliated teaching hospital. PARTICIPANTS Healthcare workers (HCWs) with unprotected exposure (not wearing N95 respirator during aerosol-generating procedure) to a patient with influenza A H7N9. METHODS A bundle approach including active and enhanced surveillance, early airborne infection isolation, rapid molecular diagnostic testing, and extensive contact tracing for HCWs with unprotected exposure was implemented. Seventy HCWs with unprotected exposure to an index case were interviewed especially regarding their patient care activities. RESULTS From April 1, 2013, through May 31, 2014, a total of 126 (0.08%) of 163,456 admitted patients were tested for the H7 gene by reverse transcription-polymerase chain reaction per protocol. Two confirmed cases were identified. Seventy (53.8%) of 130 HCWs had unprotected exposure to an index case, whereas 41 (58.6%) and 58 (82.9%) of 70 HCWs wore surgical masks and practiced hand hygiene after patient care, respectively. Sixteen (22.9%) of 70 HCWs were involved in high-risk patient contacts. More HCWs with high-risk patient contacts received oseltamivir prophylaxis (P=0.088) and significantly more had paired sera collected for H7 antibody testing (P<0.001). Ten (14.3%) of 70 HCWs developed influenza-like illness during medical surveillance, but none had positive results by reverse transcription-polymerase chain reaction. Paired sera was available from 33 of 70 HCWs with unprotected exposure, and none showed seroconversion against H7N9. CONCLUSIONS Despite the delay in airborne precautions implementation, no patient-to-HCW transmission of influenza A H7N9 was demonstrated..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
|---|---|
| Enthalten in: |
Infection control & hospital epidemiology - 36(2015), 1, Seite 87-92 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Cheng, Vincent C C [VerfasserIn] |
|---|
| Links: |
|---|
| doi: |
10.1017/ice.2014.2 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC1968516166 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1968516166 | ||
| 003 | DE-627 | ||
| 005 | 20220219175752.0 | ||
| 007 | tu | ||
| 008 | 160206s2015 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1017/ice.2014.2 |2 doi | |
| 028 | 5 | 2 | |a PQ20160617 |
| 035 | |a (DE-627)OLC1968516166 | ||
| 035 | |a (DE-599)GBVOLC1968516166 | ||
| 035 | |a (PRQ)c829-bbeb91da94020a8c4aaf7e605e29ab6ce9a200dbfec6281d694ab4cf881e38a40 | ||
| 035 | |a (KEY)0104493120150000036000100087infectioncontrolpreparednessforhumaninfectionwithi | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q DNB |
| 084 | |a 44.11 |2 bkl | ||
| 084 | |a 44.17 |2 bkl | ||
| 100 | 1 | |a Cheng, Vincent C C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Infection control preparedness for human infection with influenza A H7N9 in Hong Kong |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a OBJECTIVE To assess the effectiveness of infection control preparedness for human infection with influenza A H7N9 in Hong Kong. DESIGN A descriptive study of responses to the emergence of influenza A H7N9. SETTING A university-affiliated teaching hospital. PARTICIPANTS Healthcare workers (HCWs) with unprotected exposure (not wearing N95 respirator during aerosol-generating procedure) to a patient with influenza A H7N9. METHODS A bundle approach including active and enhanced surveillance, early airborne infection isolation, rapid molecular diagnostic testing, and extensive contact tracing for HCWs with unprotected exposure was implemented. Seventy HCWs with unprotected exposure to an index case were interviewed especially regarding their patient care activities. RESULTS From April 1, 2013, through May 31, 2014, a total of 126 (0.08%) of 163,456 admitted patients were tested for the H7 gene by reverse transcription-polymerase chain reaction per protocol. Two confirmed cases were identified. Seventy (53.8%) of 130 HCWs had unprotected exposure to an index case, whereas 41 (58.6%) and 58 (82.9%) of 70 HCWs wore surgical masks and practiced hand hygiene after patient care, respectively. Sixteen (22.9%) of 70 HCWs were involved in high-risk patient contacts. More HCWs with high-risk patient contacts received oseltamivir prophylaxis (P=0.088) and significantly more had paired sera collected for H7 antibody testing (P<0.001). Ten (14.3%) of 70 HCWs developed influenza-like illness during medical surveillance, but none had positive results by reverse transcription-polymerase chain reaction. Paired sera was available from 33 of 70 HCWs with unprotected exposure, and none showed seroconversion against H7N9. CONCLUSIONS Despite the delay in airborne precautions implementation, no patient-to-HCW transmission of influenza A H7N9 was demonstrated. | ||
| 650 | 4 | |a Antiviral Agents - therapeutic use | |
| 650 | 4 | |a Occupational Exposure - analysis | |
| 650 | 4 | |a Influenza, Human - prevention & control | |
| 650 | 4 | |a Oseltamivir - therapeutic use | |
| 650 | 4 | |a Infection Control - organization & administration | |
| 650 | 4 | |a Cross Infection - diagnosis | |
| 650 | 4 | |a Antibodies, Viral - blood | |
| 650 | 4 | |a Cross Infection - prevention & control | |
| 650 | 4 | |a Infectious Disease Transmission, Patient-to-Professional - prevention & control | |
| 650 | 4 | |a Influenza A Virus, H7N9 Subtype - isolation & purification | |
| 650 | 4 | |a Influenza A Virus, H7N9 Subtype - genetics | |
| 650 | 4 | |a Occupational Exposure - prevention & control | |
| 650 | 4 | |a Influenza A Virus, H7N9 Subtype - immunology | |
| 650 | 4 | |a Influenza, Human - transmission | |
| 650 | 4 | |a Hospitals, Teaching - organization & administration | |
| 650 | 4 | |a Influenza, Human - diagnosis | |
| 700 | 1 | |a Tai, Josepha W M |4 oth | |
| 700 | 1 | |a Lee, W M |4 oth | |
| 700 | 1 | |a Chan, W M |4 oth | |
| 700 | 1 | |a Wong, Sally C Y |4 oth | |
| 700 | 1 | |a Chen, Jonathan H K |4 oth | |
| 700 | 1 | |a Poon, Rosana W S |4 oth | |
| 700 | 1 | |a To, Kelvin K W |4 oth | |
| 700 | 1 | |a Chan, Jasper F W |4 oth | |
| 700 | 1 | |a Ho, P L |4 oth | |
| 700 | 1 | |a Chan, K H |4 oth | |
| 700 | 1 | |a Yuen, K Y |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Infection control & hospital epidemiology |d New York, NY : Cambridge University Press, 1988 |g 36(2015), 1, Seite 87-92 |w (DE-627)168134993 |w (DE-600)639378-0 |w (DE-576)018247288 |x 0195-9417 |7 nnns |
| 773 | 1 | 8 | |g volume:36 |g year:2015 |g number:1 |g pages:87-92 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1017/ice.2014.2 |3 Volltext |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/25627766 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4219 | ||
| 936 | b | k | |a 44.11 |q AVZ |
| 936 | b | k | |a 44.17 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 36 |j 2015 |e 1 |h 87-92 | ||