Advanced gastric cancer with liver and lymph node metastases successfully resected after induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil
At diagnosis, about 35% of patients with gastric cancer present with distant metastases, and most patients with gastric cancer and liver metastases are excluded from curative surgery. We report a case of human epidermal growth factor receptor-2 (HER2)-negative gastric cancer with metastases to the liver and perigastric lymph nodes. The patient (a 60-year-old man) was considered unresectable at diagnosis and was treated with palliative chemotherapy (docetaxel plus cisplatin and 5-fluorouracil by continuous intravenous infusion over 5 days every 3 weeks). However, after 6 courses of chemotherapy, a computed tomography scan showed a reduction of the liver metastasis and the disappearance of the enlarged perigastric lymph nodes. The patient then underwent a curative gastrectomy, lymphadenectomy and liver resection. After surgery, the patient was treated with 6 courses of FOLFOX-4 regimen as adjuvant chemotherapy. With a follow-up of 26 months after surgery, the patient is alive and disease free. In patients with metastatic gastric cancer, the prognosis is poor with a median overall survival of 11 months since curative treatments are excluded; however, this case illustrated that a personalized treatment with chemotherapy and surgery can allow a curative strategy in selected patients with HER2-negative advanced gastric cancer..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Chemotherapy - 60(2014), 4, Seite 224-227 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cavanna, Luigi [VerfasserIn] |
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| Links: |
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| doi: |
10.1159/000375156 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Advanced gastric cancer with liver and lymph node metastases successfully resected after induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil |
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| 520 | |a At diagnosis, about 35% of patients with gastric cancer present with distant metastases, and most patients with gastric cancer and liver metastases are excluded from curative surgery. We report a case of human epidermal growth factor receptor-2 (HER2)-negative gastric cancer with metastases to the liver and perigastric lymph nodes. The patient (a 60-year-old man) was considered unresectable at diagnosis and was treated with palliative chemotherapy (docetaxel plus cisplatin and 5-fluorouracil by continuous intravenous infusion over 5 days every 3 weeks). However, after 6 courses of chemotherapy, a computed tomography scan showed a reduction of the liver metastasis and the disappearance of the enlarged perigastric lymph nodes. The patient then underwent a curative gastrectomy, lymphadenectomy and liver resection. After surgery, the patient was treated with 6 courses of FOLFOX-4 regimen as adjuvant chemotherapy. With a follow-up of 26 months after surgery, the patient is alive and disease free. In patients with metastatic gastric cancer, the prognosis is poor with a median overall survival of 11 months since curative treatments are excluded; however, this case illustrated that a personalized treatment with chemotherapy and surgery can allow a curative strategy in selected patients with HER2-negative advanced gastric cancer. | ||
| 540 | |a Nutzungsrecht: © 2015 S. Karger AG, Basel. | ||
| 650 | 4 | |a Stomach Neoplasms - surgery | |
| 650 | 4 | |a Stomach Neoplasms - diagnosis | |
| 650 | 4 | |a Taxoids - administration & dosage | |
| 650 | 4 | |a Antineoplastic Combined Chemotherapy Protocols - administration & dosage | |
| 650 | 4 | |a Gastrectomy - trends | |
| 650 | 4 | |a Induction Chemotherapy - methods | |
| 650 | 4 | |a Cisplatin - administration & dosage | |
| 650 | 4 | |a Fluorouracil - administration & dosage | |
| 650 | 4 | |a Liver Neoplasms - diagnosis | |
| 650 | 4 | |a Liver Neoplasms - drug therapy | |
| 650 | 4 | |a Liver Neoplasms - secondary | |
| 650 | 4 | |a Stomach Neoplasms - drug therapy | |
| 650 | 4 | |a Liver | |
| 650 | 4 | |a Stomach cancer | |
| 650 | 4 | |a Lymphatic system | |
| 650 | 4 | |a Chemotherapy | |
| 650 | 4 | |a Metastasis | |
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| 700 | 1 | |a Stroppa, Elisa Maria |4 oth | |
| 700 | 1 | |a Banchini, Filippo |4 oth | |
| 700 | 1 | |a Michieletti, Emanuele |4 oth | |
| 700 | 1 | |a Capelli, Patrizio |4 oth | |
| 700 | 1 | |a Zangrandi, Adriano |4 oth | |
| 700 | 1 | |a Anselmi, Elisa |4 oth | |
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