Ruthenium metallodendrimer against triple-negative breast cancer in mice
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved..
Carbosilane metallodendrimers, based on the arene Ru(II) complex (CRD13) and integrated to imino-pyridine surface groups have been investigated as an anticancer agent in a mouse model with triple-negative breast cancer. The dendrimer entered into the cells efficiently, and exhibited selective toxicity for 4T1 cells. In vivo investigations proved that a local injection of CRD13 caused a reduction of tumour mass and was non-toxic. ICP analyses indicated that Ru(II) accumulated in all tested tissues with a greater content detected in the tumour.
| Media Type: |
Electronic Article |
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| Year of Publication: |
2023 |
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| Publication: |
2023 |
| Contained In: |
To Main Record - volume:53 |
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| Contained In: |
Nanomedicine : nanotechnology, biology, and medicine - 53(2023) vom: 15. Aug., Seite 102703 |
| Language: |
English |
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| Contributors: |
Michlewska, Sylwia [Author] |
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| Links: |
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| Keywords: |
Anticancer agent |
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| Notes: |
Date Revised 27.08.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.nano.2023.102703 |
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| funding: |
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| Supporting institution / Project title: |
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| 520 | |a Carbosilane metallodendrimers, based on the arene Ru(II) complex (CRD13) and integrated to imino-pyridine surface groups have been investigated as an anticancer agent in a mouse model with triple-negative breast cancer. The dendrimer entered into the cells efficiently, and exhibited selective toxicity for 4T1 cells. In vivo investigations proved that a local injection of CRD13 caused a reduction of tumour mass and was non-toxic. ICP analyses indicated that Ru(II) accumulated in all tested tissues with a greater content detected in the tumour | ||
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| 650 | 4 | |a Toxicity | |
| 650 | 4 | |a Tumour weight | |
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| 700 | 1 | |a Skiba, Elżbieta |e verfasserin |4 aut | |
| 700 | 1 | |a Ortega, Paula |e verfasserin |4 aut | |
| 700 | 1 | |a de la Mata, Francisco Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Bryszewska, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Ionov, Maksim |e verfasserin |4 aut | |
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